基质金属蛋白酶与动脉粥样硬化病变的关系

在正常生理情况下,基质金属蛋白酶-9能够切断任何细胞外基质成分,调节细胞黏着,作用于细胞外成分或其他蛋白成分而启动潜在生物学功能。病理状态下,潜在型基质金属蛋白酶-9可被激活并参与动脉粥样硬化时的血管壁重构、斑块破裂、血栓形成等过程。研究发现,基质金属蛋白酶-3与动脉粥样硬化过程中纤维帽的形成密切相关,同时基质金属蛋白酶-3可激活包括基质金属蛋白酶-3前体在内的其他基质金属蛋白酶,从而加速动脉粥样硬化病变的发展。

The Relationship between Matrix Metalloproteinases and Atherosclerotic Lesions

In normal physiological conditions,matrix metalloproteinases-9 not only cut off any extracellular matrix components and adjust cell adhesion,but when in the role of the extracellular matrix components or other protein composition can start the potential biological function.In the pathologic state,potential matrix metalloproteinases-9 can be activated and participate hemal wall reconstruction,plaque ruptured and thrombosis in the processes of atherosclerosis.Research has found matrix metalloproteinases-3 to be closely related to the process of the formation of the fibrous cap in atherosclerosis,at the same time matrix metalloproteinases-3 can activate matrix metalloproteinases-3 precursor and other matrix metalloproteinases,thus speeding up the development of atherosclerotic lesions.