| 组蛋白去乙酰化酶抑制剂在慢性心力衰竭中的作用及研究进展 |
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| 引用本文： | 陈海平. 组蛋白去乙酰化酶抑制剂在慢性心力衰竭中的作用及研究进展[J]. 心血管病学进展, 2012, 33(4): 541-544 |
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| 作者姓名： | 陈海平 |
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| 作者单位： | 蚌埠医学院研究生学院,安徽蚌埠233000;蚌埠医学院第一附属医院心内科,安徽蚌埠233000 |
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| 摘 要： | 心力衰竭(心衰)是一个世界范围的疾病,现阶段针对心衰的治疗只能控制患者的症状,广谱的组蛋白去乙酰化酶抑制剂(HDACi)及相关的特异性抑制剂能够阻止心脏肥大、纤维化,阻止心衰发展的进程。但其治疗心衰的具体机制仍在不断的研究中。现就组蛋白去乙酰化酶抑制剂治疗心衰的可能机制及研究进展做一综述。
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| 关 键 词： | 组蛋白去乙酰化酶抑制剂 心力衰竭 治疗 |
Progress in Research on Histone Deacetylase Inhibitors on Chronic Heart Failure |
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| CHEN Hai-ping. Progress in Research on Histone Deacetylase Inhibitors on Chronic Heart Failure[J]. Advances in Cardiovascular Diseases, 2012, 33(4): 541-544 |
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| Authors: | CHEN Hai-ping |
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| Affiliation: | 1.Graduate School of Bengbu Medical College,Bengbu 233000,Anhui,China;2.Department of Cardiology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,Anhui,China) |
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| Abstract: | Heart failure is a worldwide health problem.Current Heart failure therapies manage the symptoms,while broad-spectrum histone deacetylases inhibitors as well as class I or Ⅱ histone deacetylases-specific inhibitors prevent cardiac hypertrophy,fibrosis,and arrest the development of heart failure.However,the mechanism is unknown.This article reviews the possible mechanisms,and progress in research on histone deacetylases inhibitors on heart failure. |
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| Keywords: | histone deacetylases inhibitors heart failure treatment |
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