IgA肾病患者血清刺激系膜细胞增殖与病理改变的关系

本研究采用系膜细胞培养技术观察了38例IgA肾病患者血清对系膜细胞增殖的影响,并采用ELlSA方法检测了血清中循环免疫复合物(CIC)的浓度,结果发现,IgA肾病血清对系膜细胞的增殖有明显刺激作用,而且这种刺激作用与肾组织病理改变程度成正相关,IgA肾病血清中IgA-CIC和IgG-CIC均较正常人明显增高,但血中IgA水平与系膜增殖及病理改变程度无相关性。

The Effects of Serum from Patients with IgA Nephropathy on Cultured Glomerular Mesangial Cells

In this paper. the effects of serum from 38 patients with IgA nephropathy on cultured gloumerular mesangial cells in vitro were studied. the IgA-CIC, IgG-CIC and IgM-CIC in the serum were measured by using ELISA. The results were summarized as follows: 1. the ~3H-TdR uptake into mesangial cells was markedly enhanced (P<0.01) by the serum of IgA nephropathy on culture medium, and the increment was closely related to the severity of glomerular pathological changes (r=0.429; 2. the levels of IgA-CIC and IgG-CIC increased in the serum of patients with IgA nephropathy than those in normal controls (P<0.05); and 3. there was a close relationship between the amount of urinary protein and the degree of renal pathological changes (r=0.616).