P27 The Establishment of a New Experiment in Clinical Pharmacology Teaching

Clinical pharmacology is a newly emerging subject which is based on basic pharmacology and clinical medicine. It＇ s very important for training valid and good doctors and pharmaceutists. Rencently many universities in China have required clinical pharmacology as a special necessary course for medical and pharmacy students. But the experimental teaching in clinical pharmacology is not so wide till now in China. We have established a new clinical experiment as ＂Determination of the pharmacokinetic parameters of Ciprofloxacin in healthy young volunteers＂. The experiment was carried out with 10 healthy young volunteers after single oral administration of lOOmg Ciprofloxacin. Urine samples were collected then centrifuged at different time after administration. UV-spectrophotometry method was used to determine the concentration of Ciprofloxacin in urine. The pharmacokinetic parameters following oral administration of tested Ciprofloxacin in healthy young volunteers can be obtained by the formula that the elimination of Ciprofloxacin is conformed to one-compartment model. This method is rapid, accurate, sensitive and the most important, very convenient, it＇ s very suitable for experimental teaching in clinical pharmacology. This new clinical experiment can be widely spread through all the medical and pharmaceutical universities.

P27 The Establishment of a New Experiment in Clinical Pharmacology Teaching