| 紫草素抑制卵巢癌作用机制的研究进展 |
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| 引用本文： | 杲飞莹,卢丹.紫草素抑制卵巢癌作用机制的研究进展[J].中草药,2021,52(23):7358-7363. |
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| 作者姓名： | 杲飞莹 卢丹 |
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| 作者单位： | 扬州大学临床医学院 扬州大学转化医学研究中心 江苏省中西医结合老年病防治重点实验室, 江苏 扬州 225000 |
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| 基金项目： | 国家自然科学基金资助项目（82072088）；江苏省中医药局科技项目（YB201972）；江苏省研究生科研创新计划项目（KYCX21_3291） |
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| 摘 要： | 紫草为紫草科植物新疆紫草Arnebia euchroma或内蒙紫草A.guttata的干燥根，《中国药典》记载其具有清热凉血、活血解毒、透疹消斑的功效。紫草素是从紫草中提取出来的萘醌类化合物，目前，紫草素及其衍生物在各种癌症的治疗中被广泛研究。主要从机体的免疫系统、肿瘤细胞的侵袭和转移、肿瘤细胞凋亡、肿瘤细胞的有氧糖酵解及肿瘤细胞周期5个方面综述紫草素抑制卵巢癌作用机制的研究进展，为紫草素治疗卵巢癌的临床研究提供参考依据。
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| 关 键 词： | 紫草 紫草素 卵巢癌 免疫系统 细胞凋亡 有氧糖酵解 细胞周期 |
| 收稿时间： | 2021/3/22 0:00:00 |
Research progress on mechanism of shikonin inhibiting ovarian cancer |
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| GAO Fei-ying,LU Dan.Research progress on mechanism of shikonin inhibiting ovarian cancer[J].Chinese Traditional and Herbal Drugs,2021,52(23):7358-7363. |
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| Authors: | GAO Fei-ying LU Dan |
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| Institution: | Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Translational Medicine Research Center of Yangzhou University, College of Clinical Medicine, Yangzhou University, Yangzhou 225000, China |
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| Abstract: | Arnebiae Radix are the dry roots of Arnebia euchroma from Xinjiang or A. guttata from Inner Mongolia with the efficacies of clearing heat and blood, activating blood and removing toxin, promoting eruption and dispersing speckle documented in Chinese Pharmacopoeia. Shikonin is a naphthoquinone compound extracted from the Chinese herb Comfrey. Currently, shikonin and its derivatives are widely studied in treatment of different types of cancer. Research progress on mechanism of shikonin inhibiting ovarian cancer from five aspects including body immune system, invasion and metastasis of tumor cells, apoptosis of tumor cells, aerobic glycolysis of tumor cells and tumor cell cycle are reviewed in this paper, in order to provide reference for clinical study of shikonin in treatment of ovarian cancer. |
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| Keywords: | Arnebiae Radix shikonin ovarian cancer immune system cell apoptosis aerobic glycolysis cell cycle |
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