| 注射用盐酸万古霉素与三种常用电解质注射液的配伍稳定性考察 |
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| 引用本文： | 刘钢,秦侃,袁杰,吴文华. 注射用盐酸万古霉素与三种常用电解质注射液的配伍稳定性考察[J]. 实用药物与临床, 2019, 22(4): 425-428 |
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| 作者姓名： | 刘钢 秦侃 袁杰 吴文华 |
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| 作者单位： | 安徽医科大学第三附属医院药学部,合肥,230061;安徽省食品药品检验研究院,合肥,230051;安徽省食品药品审评认证中心,合肥,230051 |
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| 摘 要： | 目的考察注射用盐酸万古霉素与3种常用电解质注射液的配伍稳定性。方法考察室温条件下8 h内3种不同配伍液的外观、pH值变化;采用高效液相色谱法测定配伍液在25、40℃时避光、光照条件下注射用盐酸万古霉素的含量变化。结果室温条件下8 h内3种不同配伍液的外观、pH值均无明显变化;25℃下8 h内3种不同配伍液在避光、光照条件下的万古霉素含量均无明显变化;40℃下6 h后3种不同配伍液在避光、光照条件下的万古霉素含量均有小幅降低。结论注射用盐酸万古霉素与3种常用电解质注射液临床均可配伍使用,但应注意控制配伍环境温度,以不超过30℃为宜,并且配伍液应在6 h内使用。
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| 关 键 词： | 万古霉素 电解质注射液 配伍 稳定性 |
Compatible stability of vancomycin hydrochloride for injection with three common electrolyte injections |
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| LIU Gang,QIN Kan,YUAN Jie,WU Wen-hua. Compatible stability of vancomycin hydrochloride for injection with three common electrolyte injections[J]. Practical Pharmacy and Clinical Remedies, 2019, 22(4): 425-428 |
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| Authors: | LIU Gang QIN Kan YUAN Jie WU Wen-hua |
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| Affiliation: | (Department of Pharmacy,the Third Affiliated Hospital of Anhui Medical University,Hefei 230061,China;Anhui Provincial Institute for Food and Drug Control,Hefei 230051,China;Anhui Provincial Center for Food and Drug Evaluation and Certification Heifei 230051,China) |
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| Abstract: | LIU Gang;QIN Kan;YUAN Jie;WU Wen-hua(Department of Pharmacy,the Third Affiliated Hospital of Anhui Medical University,Hefei 230061,China;Anhui Provincial Institute for Food and Drug Control,Hefei 230051,China;Anhui Provincial Center for Food and Drug Evaluation and Certification Heifei 230051,China) |
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| Keywords: | Vancomycin Electrolyte injection Compatibility Stability |
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