通脉降脂口服液抗动脉粥样硬化作用的实验研究

将日本大耳白兔２７只随机分为３组，观察中药通脉降脂口服液在实验性动脉粥样硬化形成中降低血脂，减轻脂质过氧化损伤，调节前列腺素代谢及减轻粥样斑块形成作用。结果表明：通脉降脂口服液可明显地降低实验动物血清胆固醇（ＴＣ），甘油二酯（ＴＧ），血浆酯质过氧化物（ＬＰＯ）及血栓素Ｂ２（ＴＸＢ２）的含量，升高全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性，调节血栓素Ｂ２／６－酮－前列环素（６－ｋｅｔｏ－ＰＧＦ１α）

Experimental Study on Anti-Atherosclerotic Effect of Tongmai Jiangzhi Oral Liquor

Japanese white male rabbits were divided into 3 groups for evaluation of Tongmai Jiangzhi Oral Liquor(TMJZ)in reducing the serum cholesterol,the level of plasma lipid peroxidation(LPO),the plasma TXB 2 and suppressing of atherosclerotic plaque formation in atherogenesis.The results indicated that TMJZ not only decreased significantly the levels of serum cholesterol,triglyceride,LPO and TXB 2,but also increased markedly blood glutathion peroxidase(GSH-Px) activity and regulated the balance of TXB2/6-keto-PGF la. The area of atherosclerotic plaque coverage in aorta and the thickness of plaque after oral TMJZ were much smaller than those of high -cholesterol-fed rabbits.It is suggested that the effect of TMJZ on above-mentioned indexes might be important mechanism of its anti-atherosclerotic effect.