藏药红景天复方对犬实验性心肌缺血时心脏血流动力学的影响

采用健康杂种犬造成心肌缺血模型，以平均动脉压、左心室终末压、心率、心输出量及心脏指数等血流动力学指标，观察藏药红景天复方对实验性心肌缺血的影响，结果表明，心肌缺血可使ＬＶＥＤ明显升高，ＭＡＰ、ＣＯ及ＣＩ等明显降低，提示心肌缺血后心脏血流动力学紊乱，给药组药后心肌缺血过程中ＣＯ明显增加，ＣＩ亦显著增高，提示该复方可增强缺血心脏的泵血功能，在一定程度上纠正了因缺血引起的心脏血流动力学的紊乱。

Effect of Tibetan Compound prescription on Cardiac Haemodynamics in Experimental Myocardial lschemia in Dogs

healthy and hybrid dogs were divided into the control group(5 dogs),lschemic group(15dogs) and medicated group(15 dogs).The myocardial ischemia model was produced by ligating the left coronary artery between the branch 2 and 3 among the anterior descending branches.The effect of the herbs on the experimental myocardial ischemia was observed by measurring the Mean Artery Pressure(MAP),the Left Ventricular End Diastolic Pressure(LVEDP),the Heart Rate(HR),the Cardiac Output(CO) and the Cardiac index(CI) etc.The results showed that the LVEDP was significantly increased and the MAP,the CO and the CI were lowered during the period of myocardial ischemia,which indicated the disorder of cardiac heaemodynamics after the myocardial ischemia,By taking the medicine through the duodenum in the medicated group,the CO was obviously increased during the period of myocardial ischemia and also the CI was elevated prominently.The investigation indicated that the medicine could reinforce the cardiac pump function and adjust the disorder of cardiac haemodynamics resulted from myocardial ischemia.