大鼠辅助肝移植病理改变

将Ｗｉｓｔａｒ大白鼠随机发Ａ、Ｂ、Ｃ三组，分别于辅助肝移植术后２、６和１２天处死。用光镜和电镜观察供肝病理变化。结果（１）Ａ组呈肝细胞增生明显，核大、核仁大，线粒体和粗面内质网增生；（２）Ｂ组可见肝细胞脂肪变性，线粒体肿胀以及血管周转有单核细胞，淋巴细胞浸润；（３）Ｃ组肝细胞丧失伴大量坏列经和纤维组织增生。

Pathological Changes of auxiliary liver allografts in the rat

Wistar rats randomly divided into groups A, B and C were killed at 2.3 and 12 days after transplantation, respectively. The pathological changes of the donor livers were observed by light microscope and electron microscope. The findings demonstrated that: (1 ) in the group A there was hepatocellular regeneration including hypertrophy of nuclei and nucleoli, and hyperplasia of mitochondrions and endoplasmic reticula; (2) in the group B the morphologic changes of the allografts involved in distinet fatty degencration and mitochondrial swelling of hepatic cells and peripheral vesscl wall infiltration by monocytes and lymphocytes; (3)in the group C hepatocellular loss with the massive tissue necrosis and fibroplasia occurred in the gratfs. From the above it was concluded that hepatocellular necrosis or loss related to the rejection 12 days after the transplantation might lead to the liver failure in the rats.