IL-6、IL-8、TNF-α在慢性胃炎患儿血清变化意义研究

目的探讨白介素-6 (IL-6)、白介素-8 (IL-8)、肿瘤坏死因子-α(TNF-α)在慢性胃炎患儿血清变化中的意义。方法选取2014年9月至2018年11月于郑州大学附属儿童医院进行慢性胃炎治疗的患儿120例临床资料进行分析,同时选取115例正常健康体检儿童的临床资料作为对照组。检测各组患儿血清中IL-6、IL-8、TNF-α水平和各个指标的特异度、灵敏度情况。结果慢性胃炎患儿血清中IL-6、IL-8、TNF-α表达水平明显高于健康组(P<0.05)。同时检测表明IL-6、IL-8、TNF-α三者联合诊断的特异度、灵敏度高于单一检测(P<0.05)。随着治疗时间的增加,慢性胃炎患儿血清中的IL-6、IL-8、TNF-α水平逐渐下降(P<0.05)。结论 IL-6、IL-8、TNF-α水平在慢性胃炎的发生发展中不断变化,为精准诊断慢性胃炎提供了新的思路。

Significance of serum levels of IL-6,IL-8 and TNF-alpha in children with chronic gastritis

【Objective】To explore the significance of serum levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-alpha(TNF-alpha)in children with chronic gastritis.【Methods】One hundred and twenty children with chronic gastritis treated in our hospital from September 2014 to November 2018 were selected,and 115 children with normal physical examination were selected as control group.The serum levels of IL-6,IL-8,TNF-alpha and the specificity and sensitivity of each index were detected.【Results】The levels of IL-6,IL-8 and TNF-alpha in serum of children with chronic gastritis were significantly higher than those of healthy children(P<0.05).At the same time,the expression of IL-6,IL-8 and TNF-alpha in combination was more specific and sensitive(P<0.05).After treatment,the serum levels of IL-6,IL-8 and TNF-alpha in children with chronic gastritis gradually decreased with the increase of treatment time(P<0.05).【Conclusion】Interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-alpha(TNF-alpha)are constantly changing in the occurrence and development of chronic gastritis,which provides a new way for accurate diagnosis of chronic gastritis.