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Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures study |
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| Authors: | Gregory A Wellenius Gloria Y Yeh Brent A Coull Helen H Suh Russell S Phillips Murray A Mittleman |
| Affiliation: | (1) Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, , 330 BrooklineAvenue, Boston, MA 02215, USA;(2) Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, , 330Brookline Avenue, Boston, MA 02215, USA;(3) Department of Biostatistics, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA;(4) Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA |
| Abstract: | BackgroundStudies using administrative data report a positive association between ambient air pollution and the risk of hospitalization for congestive heart failure (HF). Circulating levels of B-type natriuretic peptide (BNP) are directly associated with cardiac hemodynamics and symptom severity in patients with HF and, therefore, serves as a marker of functional status. We tested the hypothesis that BNP levels would be positively associated with short-term changes in ambient pollution levels among 28 patients with chronic stable HF and impaired systolic function. |
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