注射用苦参素纳米球与普通粉针剂在大鼠体内药动学比较

目的 比较注射用苦参素纳米球（KU-PLGA-NS）与注射用苦参素普通粉针剂（KUI）在大鼠体内的药动学特性。方法 建立HPLC法检测大鼠血浆中苦参素，采用ANOVA法选择房室模型，将所测得的血药浓度-时间数据，采用DAS程序进行分析，根据F值与AIC选择房室模型求算药动学参数。结果 等剂量KU-PLGA-NS和KUI的AUC_0-t分别为（785.57±170.92）、（342.43±54.49）mg·L^?1·min，C_max为（18.51±2.47）、（28.48±5.40）mg/L，t_1/2Ke为（91.69±1.94）、（11.51±2.47）min。结论 KU-PLGA-NS在大鼠体内的药动学特性与KUI比较AUC和C_max增加，t_1/2延长。

Pharmacokinetic comparison between Kushenin Injection Nanoparticles and common injection in rats

Objective To compare the in vivo pharmacokinetic properties of Kushenin Injection Nanoparticles (KU-PLGA-NS) with the ordinary Kushenin Injection (KUI) of rats. Methods A method has been developed and validated for the quantification of kushenin in rat plasma. Using ANOVA method to choose the compartment model, The plasma concentration-time data were measured and then analyzed by DAS program on the computer. According to F values, the AIC choice compartment model pharmacokinetic parameters were calculated. Results The main pharmacokinetic parameters of KU-PLGA-NS and KUI were as follows: AUC_0-t were (785.57 ± 170.92) and (342.43 ± 54.49) mg·L^?1·min, respeticevly; C_max were (18.51 ± 2.47) and (28.48 ± 5.40) mg/L, respeticevly; t_1/2Ke were (91.69 ± 1.94) and (11.51 ± 2.47) min, respeticevly. Conclusion Comparison of ordinary powder injection, kushenin nanoparticles in vivo of rats pharmacokinetic characteristics between KU-PLGA-NS and KUI has a significant change, with AUC and C_max increase, and t_1/2 extension.