246例血清同型半胱氨酸测定结果的临床分析

目的通过对246例血清同型半胱氨酸(Hcy)测定结果的临床分析,探讨Hcy测定的临床意义。方法应用德国拜耳1650型全自动生化分析仪测定246例住院及门诊患者血清Hcy浓度。结果 55岁以上者Hcy测定结果与55岁以下者差异无统计学意义(P0.05);55岁以上者Hcy阳性率为23.96%,55岁以下者为56.67%,55岁以下者Hcy阳性率明显高于55岁以上者,差异有统计学意义(P0.01);女性Hcy阳性率为41.51%,男性为52.58%,男性明显高于女性,差异有统计学意义(P0.01)。结论 Hcy作为心脑血管疾病的独立致病危险因素,其值增高的患者容易诱发心脑血管疾病。临床应该尽早开展Hcy常规检查,以方便对心脑血管疾病的早期筛查、早期诊断和早期治疗,对于早期干预心脑血管病的危险因素,减少缺血性心脑血管病的发病有重要的临床意义。

Clinical analysis of 246 cases of serum homocysteine measurement results

Objective To study the clinical significance of homocysteine（Hcy） detection by analyzing the results in 246 cases of determination of serum Hcy.Methods Using the German Bayer 1650 automatic biochemical analyzer,246 inpatients and outpatients were detected for serum Hcy concentration.Results The results of Hcy detection in the patients over 55 years old had no significant difference compared with the patients under 55 years old（P0.05）.The positive rate of Hcy in the patients over 55 years old was 23.96%,while that in the patients under 55 years old was 56.67%,the later was significantly higher than the former（P0.01）.The Hcy positive rate of female was 41.51%,while that of male was 52.58%,male＇s was significantly higher than female＇s（P0.01）.Conclusion Hcy as an independent risk factor of cardiocerebral vascular disease,its increase is likely to cause the cardiocerebral vascular diseases.Clinical routine examination of Hcy should be carried out as soon as possible in order to facilitate the early screening,early diagnosis and early treatment of cardiocerebral vascular diseases.Early intervention to the risk factors of cardiocerebral vascular disease has important clinical significance to reduce ischemic cardiocerebral vascular diseases.