Quantitative production of prostaglandin E2 and its metabolites by human fetal membranes |
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| Authors: | H KHAN M H F SULLIVAN R HELMIG C K ROSEBLADE N ULDBJERG M G ELDER |
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| Institution: | Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W1Z OHS;Y-Forskningslaboratorium, Gynaekologisk-Obstetrisk afd. Y., Arhus Kommunehospital, 8000 Arhus C., Denmark |
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| Abstract: | Summary. Cultured amnion, choriodecidua and intact fetal membrane produced similar quantities of prostaglandin E2 (PGE2) (1–5 ng/ml). Choriodecidua and intact fetal membrane also produced very high levels of PGE2 metabolites (100–1000 ng/ml). The total production of PGE (PGE2 metabolites) was similar in intact fetal membrane and in choriodecidua, suggesting that the amnion, although a source of PGE2 contributes little to the overall PGE production by fetal membranes. |
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