Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer’s disease brain |
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| Authors: | Akinori Takeda Takeshi Yasuda Toshio Miyata Yoji Goto Masakazu Wakai Masaki Watanabe Yoshinari Yasuda Katsunori Horie Toshiaki Inagaki Manabu Doyu Kenji Maeda G. Sobue |
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| Affiliation: | (1) Department of Neurology, Nagoya University School of Medicine, Tsurumai 65, Showa, Nagoya 466, Japan Tel.: 81-52-744-2385; Fax: 81-52-744-2384; e-mail: sobueg@tsuru.med.nagoya-u.ac.jp, JP;(2) Department of Neurology, Oyamada Memorial Spa Hospital, Yokkaichi, Japan, JP;(3) Institute of Medical Sciences and Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan, JP;(4) Department of Neurology, Nagoya the First Red Cross Hospital, Nagoya, Japan, JP;(5) Department of Internal Medicine, Daikou Medical Center, Nagoya University School of Medicine, Nagoya, Japan, JP;(6) Department of Internal Medicine, Nagoya City Kouseiin Geriatric Hospital, Nagoya, Japan, JP |
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| Abstract: | In the previous study [Takeda et al. (1996) Neurosci Lett 221: 17–21], we reported that the advanced glycation end products (AGEs) in the external space of neuronal perikarya (extraneuroperikaryal AGE deposits) were significantly abundant in the Alzheimer’s brain. In this study, we investigated the spatial relationship of the extraneuroperikaryal AGE (carbocymethyllysine and pentosidine) deposits in astrocytes and microglial cells in the Alzheimer’s disease brain using double immunolabelling for AGEs and astrocyte or microglial cell markers. Most of the extraneuroperikaryal AGE deposits were co-localized with glial fibrillary acidic protein-positive astrocytes. AGE deposit-bearing astrocytes also contained Gomori-positive granules. Furthermore, some of the extraneuroperikaryal AGE deposits were co-localized with microglial cells. These extraneuroperikaryal AGEs may activate astrocyte and microglia, and play a role in pathogenesis of Alzheimer’s disease. Received: 8 September 1997 / Revised: 19 November 1997 / Accepted: 12 February 1998 |
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| Keywords: | Advanced glycation end products Alzheimer’ s disease Astrocytes Microglia |
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