| 问荆硅化物对四氯化碳急性肝损伤的保护作用及机制 |
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| 引用本文： | 骆勤,鞠洋,党月兰,宋平顺.问荆硅化物对四氯化碳急性肝损伤的保护作用及机制[J].兰州医学院学报,2008,34(3). |
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| 作者姓名： | 骆勤 鞠洋 党月兰 宋平顺 |
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| 作者单位： | [1]兰州大学第二医院药剂科,甘肃兰州730030 [2]兰州大学药学院,甘肃兰州730000 [3]甘肃省药品检验所,甘肃兰州730000 |
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| 摘 要： | 目的 研究问荆硅化物(SCE)对CCl4急性肝损伤的保护作用及机制.方法 采用小鼠CCl4急性肝损伤模型进行实验,检测小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、NO及肝糖原、肝蛋白、肝甘油三酯、肝丙二醛、肝细胞色素P450含量及肝超氧化物歧化酶(SOD)活性.结果 SCE(灌胃1.0～2.0g/kg)能明显降低CCh肝损伤小鼠血清ALT、AST活性、NO含量及肝甘油三酯、肝丙二醛含量,提高肝糖原、肝蛋白、肝细胞色素P450含量及肝SOD活性.结论 SCE对CCl4引起的小鼠急性肝损伤具有明显保护作用,其机制可能与其清除自由基、抑制脂质过氧化及降低NO浓度有关.
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| 关 键 词： | 问荆硅化物 四氯化碳肝损伤 保肝作用 脂质过氧化 |
Protective actions and mechanisms of silicon compound of equisetum in carbon tetrachloride induced acute liver injury of mice |
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| Luo Qin Ju Yang DANG Yue-lan SONG Ping-shun.Protective actions and mechanisms of silicon compound of equisetum in carbon tetrachloride induced acute liver injury of mice[J].Journal of Lanzhou Medical College,2008,34(3). |
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| Authors: | Luo Qin Ju Yang DANG Yue-lan SONG Ping-shun |
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| Institution: | Luo Qin~1 Ju Yang~1 DANG Yue-lan~2 SONG Ping-shun~3 (1.Department of Pharmacy,the Second Hospital of Lanzhou University,Lanzhou 730030,China,2.School of Pharmacy,Lanzhou University,Lanzhou 730000,3.Institute for Drug Control of Gansu Province,China) |
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| Abstract: | Objective To study the protective actions and mechanisms of silicon compound of equisetum(SCE) in CCl_4 induced acute liver injury of mice.Methods The model of CCl_4- induced acute liver injury of mice was used.Serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),NO and liver triglycerides,protein,glycogen,malondiadehgde,hepato- cyte cytochrome P_(450)(P_(450)),superoxide dismutase(SOD) were detected to evaluate the protective actions of SCE on CCl_-induced acute liver injury.Results SCE(ig,1... |
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| Keywords: | silicon compound of equisetum carbon tetrachloride hepatic injury protective action of liver lipid peroxidation |
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