Zacopride, a potent 5-HT3 antagonist |
| |
| Authors: | W W Smith L F Sancilio J B Owera-Atepo R J Naylor L Lambert |
| |
| Affiliation: | Department of Pharmacology, A. H. Robins Co., Richmond, VA 23220. |
| |
| Abstract: | The substituted benzamide derivative zacopride was found to antagonize competitively the effects of 5-hydroxytryptamine (5-HT) on the guinea-pig ileum, the rabbit vagus nerve and the von Bezold Jarisch reflex in the rat. The potency of zacopride was comparable with that of ICS 205-930 and it is concluded that zacopride possesses 5-HT3 receptor antagonizing properties. |
| |
| Keywords: | |
|
|
