| 2-甲砜基嘧啶类化合物的合成及其用于活性染料的制备 |
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| 引用本文： | 朱正华,程铸生,段彩明,俞荣根,郝致民.2-甲砜基嘧啶类化合物的合成及其用于活性染料的制备[J].医学教育探索,1986(6). |
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| 作者姓名： | 朱正华 程铸生 段彩明 俞荣根 郝致民 |
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| 作者单位： | 华东化工学院精细化工系
(朱正华，程铸生，段彩明，俞荣根)，华东化工学院精细化工系(郝致民) |
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| 摘 要： | 以硫脲为原料,经甲基化(产率为96%、文献值为84%)成环缩合(产率为97.4%、文献值为89.7%).氯化氯代(产率为70.7%)、氧化(产率为80.7%)得到活性基团:2-甲砜基-4,5-二氯-6-甲基嘧啶。总产率为53.5%。并从硫脲和丙二酸二乙酯出发,经过一系列中间步骤合或了2-甲砜基-4.6-二氯-5-取代基-5-甲基、氢、溴、氯、嘧啶。可作为活性中间体用以制备一系列活性染料。
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| 关 键 词： | 嘧啶 环化 中间体 硫脲类 合成 活性染料 活性基团 甲砜基 |
The syntheses of 2-methylsulphonyl pyrimidine compounds and their application to the preparation of reactive dyes |
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| Zhu Zhenghu,Cheng Zhusheng,Duan Caiming,Yu Ronggen and Hao Zhimin.The syntheses of 2-methylsulphonyl pyrimidine compounds and their application to the preparation of reactive dyes[J].Researches in Medical Education,1986(6). |
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| Authors: | Zhu Zhenghu Cheng Zhusheng Duan Caiming Yu Ronggen and Hao Zhimin |
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| Institution: | Department of Fine Chemicals |
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| Abstract: | With thiourea as raw material 2-methylsulphonyl-4,5-dichloro-6-methylpyrimidine has been prepared, through methylation, cyclization, chloration and oxidation giving a total yield of 53.5%. And starting with thiourea and diethylmalonate, reactive intermediates, 2-methyl-4,6-dichloro-5-substituted (-5-Me, H, Br, Cl) pyrimidine, have also been synthesized through a series of intermediate steps. All of them can be used for the preparation of a series of reactive dyes. |
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| Keywords: | pyrimidine cyclization intermediate thioureas synthesis reactive dyes reactive group methylsulphonyl |
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