| 内蒙古地区1132例遗传咨询者染色体分析 |
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| 引用本文： | 王晓华,冀小平,董弘,冯莉. 内蒙古地区1132例遗传咨询者染色体分析[J]. 包头医学院学报, 2004, 20(1): 29-30 |
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| 作者姓名： | 王晓华 冀小平 董弘 冯莉 |
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| 作者单位： | 内蒙古妇幼保健院遗传科,内蒙古,呼和浩特,010020 |
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| 摘 要： | 目的:探讨染色体异常在遗传咨询者中的发生及分布情况.方法:取受检者外周血进行淋巴细胞培养,常规收获制片,G显带处理、分析.结果:分析1 132例遗传咨询者核型,检出染色体异常76例,染色体异常检出率为6.71%.其中常染色体数目异常42例(占55.26%),性染色体异常17例(占22.37%),平衡易位7例(占9.21%),罗伯逊易位5例(占6.58%),倒位4例(占5.26%),缺失1例(占1.32%).结论:智力低下、生长发育迟缓以及生育异常与染色体异常有关,对这些患者进行染色体核型分析在治疗上有指导意义.
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| 关 键 词： | 染色体 核型分析 染色体异常 |
| 文章编号： | 1006-740X(2004)01-0029-02 |
| 修稿时间： | 2004-02-16 |
Chromosome Analysis of 1 132 Patients Seeking Genetic Counseling in Inner Mongolia Region |
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| WANG Xiaohua,JI Xiaoping,DONG Hong,et al.. Chromosome Analysis of 1 132 Patients Seeking Genetic Counseling in Inner Mongolia Region[J]. Journal of Baotou Medical College, 2004, 20(1): 29-30 |
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| Authors: | WANG Xiaohua JI Xiaoping DONG Hong et al. |
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| Abstract: | Objective: To investigate the occurrence and distribution of chromosome abnormality in patients seeking genetic counseling.Methods: Get circumference blood to cultivate lymphocyte, produce according to routine procedure and then undergo G strap analysis. Results: 76 cases with abnormal chromosome (6.71%) were found in 1132 patients seeking genetic counseling. Among them, 42 cases (55.26%) were with autosome number abnormality, 17 cases (22.37%) were with allosome abnormality, 7 cases (9.21%) were with reciprocal translocation, 5 cases (6.58%) were with Robertson translocation, 4 cases (5.26%) were with inversion, 1 case (1.32%) was with deletion.Conclusion: Chromosome abnormality is one of the cause related to mental retardation, stunted growth, and abnormal procreation. Karyotype analysis carried out towards these patients is of significance in directing appropriate treatment. |
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| Keywords: | Chromosome Karyotype analysis Chromosome abnormality |
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