Activation of supraoptic magnocellular neurons by gamma2-melanocyte stimulating hormone (γ2-MSH) |
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Authors: | L. D. Mitchell M. F. Callahan L. D. Wilkin K. A. Gruber A. K. Johnson |
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Abstract: | The effects of intracarotid infusions of the peptide gamma2-melanocyte stimulating hormone (γ2-MSH) on electrophysiologically and immunohistochemically identified supraoptic nucleus (SON) units were investigated Over a wide dose range this agent always excited SON units, while control infusions of vehicle had no effect. Because neural responses invariably preceded blood pressure elevation, it appears that γ2-MSH excitation of the magnocellular system was due to a direct effect on the central nervous system and was not a result of systemic cardiovascular responses. These results suggest a forebrain γ2-MSH sensitive site in the activation of SON magnocellular neurons. |
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Keywords: | γ 2-Melanocyte stimulating hormone Vasopressin Magnocellular neuron Supraoptic nucleus |
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