肝硬化患者血清一氧化氮水平测定及其临床意义

目的：了解肝硬化患者血清一氧化氮（NO）水平的变化，并探讨其临床意义。方法：采用分光光度法检测64例肝硬化患者及30例正常人血清NO水平。结果：肝硬化患者血清NO水平显著升高（P＜0．01），而且其升高水平在失代偿、有腹水、肝功能分级差，伴有并发症的患者较代偿、无腹水、肝功能分级好，不伴有并发症的患者明显（0．01＜P＜0．05）。结论：肝硬化患者血清NO水平升高，可能与疾病活动情况、腹水形成、肝功损害，并发症发生及预后等有关。

Determination of the levels of serum nitric oxide in patients with hepatic cirrhosis and its clinical significance

Objective: To investigate the changes of serum nitric oxide (NO) levels in patients with hepatic cirrhosis and to discuss its clinical significance. Methods: Spectrophotometry was used to determine the levels of serum NO in 64 patients with hepatic cirrhosis and 30 normal subjects. Results: Comparing with the controls, the levels of serum NO increased significantly ( P <0 01) in patients with hepatic cirrhosis. And the increased levels were more significant in patients who had decompensation, ascites, poor hepatic function grades and complications than in those who had compensation, no ascites, better hepatic function grades and no complications (0 01< P <0 05). Conclusion: The levels of NO in serum increase in patients with hepatic cirrhosis. The higher NO may be associated with the active degree of the disease, the formation of ascites, the impairment of the liver function, the occurrence of complications and the prognosis. [