Urinary levels of proteins and metabolites in workers exposed to toluene |
| |
Authors: | T P Ng S G Ong W K Lama M G Jones C K Cheung and C N Ong |
| |
Institution: | (1) Department of Community, Occupational and Family Medicine, National University Hospital of Singapore, Lower Kent Ridge, 0511, Republic of Singapore;(2) Department of Community Medicine, University of Hong Kong, Hong Kong;(3) Department of Chemistry, Stanford University, California, USA;(4) Department of Chemical Pathology, Prince of Wales Hospital, Hong Kong |
| |
Abstract: | Summary We measured urinary excretion of albumin and retinol-binding proteins to investigate the occurrence of early renal dysfunction
in 45 paint workers exposed principally to toluene, and in the same number of unexposed control subjects matched individually
for sex and age. Two biological indicators of personal toluene absorption, namely urine hippuric acid and o-cresol, were also
measured in the exposed subjects. A significantly higher level and increased prevalence of elevated retinol-binding protein
in the urine of exposed workers was found, whereas no significant difference in urinary albumin concentration was seen between
the two groups. Urinary concentrations of retinol-binding protein was correlated (r = 0.399, P < 0.006) with that of o-cresol, but not with hippuric acid or employment duration. The results suggest a dose-dependent early
tubular effect due to toluene exposure that might be useful for monitoring individuals exposed to toluene at work. |
| |
Keywords: | Toluene O-cresol Hippuric acid Retinol-binding protein Albumin |
本文献已被 SpringerLink 等数据库收录! |
|