| 高渗透压对豚鼠耳蜗离体外毛细胞膜电位的影响 |
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| 引用本文： | 江继平,黄以乐.高渗透压对豚鼠耳蜗离体外毛细胞膜电位的影响[J].临床耳鼻咽喉头颈外科杂志,1998,12(5):223-225. |
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| 作者姓名： | 江继平 黄以乐 |
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| 作者单位： | 1. 北京,解放军305医院耳鼻咽喉科,100017
2. 广州,珠江医院耳鼻咽喉科 |
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| 摘 要： | 为了解高渗透压对豚鼠耳蜗离体活外毛细胞膜电位及细胞长度的影响。我们运用粘附式细胞仪和膜电位敏感针ＤｉＢＡＣ，对豚鼠耳蜗离体外细胞在高渗环境中的膜电位相对值及细胞长度的变化进行了动态测定。
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| 关 键 词： | 高渗透压 毛细胞 膜电位 内耳眩晕 |
Effects of hypertonic solution on the membrane potential of isolated outer hair cell in the guinea pig cochlear |
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| Jiang Jiping,Huang Yile.Effects of hypertonic solution on the membrane potential of isolated outer hair cell in the guinea pig cochlear[J].Journal of Clinical Otorhinolaryngology,1998,12(5):223-225. |
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| Authors: | Jiang Jiping Huang Yile |
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| Institution: | Department of Otolaryngology, 305 Hospital of PLA, Beijing 100017. |
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| Abstract: | To learn effects of hypertonic solution on the membrane potential and cell length of isolated outer hair cell in the guinea pig cochlear, we determined the membrane potential and cell length during hypertonic activation with ACAS 570 and the membrane potentia1 sensitive probeDiBAC4(3). The results showed that the hypertonic activation depolarized the outer hair cell and made it elongate. We think that the outer hair cell has activity,the depolarization and elongation ofthe outer hair cell caused by hypertonic solution are cyto-electrophysiological basis of hearing loss and recruitment in Meniere's disease. |
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| Keywords: | Hypertonic solution Outer hair cell Membrane potential Guinea pig |
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