| 急性早幼粒细胞白血病患者诱导分化治疗前后血清IL-2受体的变化及意义 |
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| 引用本文： | 姜国胜,孙关林,陈淑蓉,吴文,李秀松.急性早幼粒细胞白血病患者诱导分化治疗前后血清IL-2受体的变化及意义[J].中国免疫学杂志,1993(5). |
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| 作者姓名： | 姜国胜 孙关林 陈淑蓉 吴文 李秀松 |
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| 作者单位： | 上海第二医科大学附属瑞金医院血研所 上海200025
(姜国胜，孙关林，陈淑蓉，吴文)，上海第二医科大学附属瑞金医院血研所 上海200025(李秀松) |
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| 摘 要： | ELISA 法检测27例急性早幼粒细胞白血病患者(APL)血清白细胞介素2受体(sIL-2R)水平.结果表明APL 患者血清sIL-2R 高于正常对照(P<0.01),经维甲酸治疗后逐渐降低,但治疗中期患者血清sIL-2R 仍高于正常和治疗后(缓解期)患者血清sIL-2R(P<0.05)。治疗后血清sIL-2R 虽略高于正常对照。却已恢复正常范围(P<0.05)。同时发现治疗中WBC 却明显升高,治疗后又下降,L-CFU 数随治疗逐渐降低并与病情同步变化。经相关分析,L-CFU 与血清sIL-2R 成正向相关(r=0.737)(P<0.01),而与WBC总数无明显相关性(P>0.05)。
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| 关 键 词： | 急性白血病 诱导分化 白细胞介素2受体 |
Studies on Serum sIL-2R level of Patients With Acute Promyeilocytic Leukemia Before and After Retinoic Acid Treatment |
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| JIANG Guo-sheng,et al..Studies on Serum sIL-2R level of Patients With Acute Promyeilocytic Leukemia Before and After Retinoic Acid Treatment[J].Chinese Journal of Immunology,1993(5). |
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| Authors: | JIANG Guo-sheng |
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| Institution: | JIANG Guo-sheng,et al. Shanghai Institute of Hematology,Shanghai Rui-Jin Hospital,Shanghai 200025 |
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| Abstract: | Method of sandwich ELISA has been used to detect the serum sIL-2R levels of 27 cases ofpatients with acute promyelocytic leukemia (APL).The results showed that level of serum sIL-2R of the APL was significantly higher than that of control groups (p<0.01).on the otherhand,we detected wariation of serum sIL-2R of 22 cases of patients with APL before intermi-tant and after treatment with all-trans retinoic acid (RA).It was found that the level of serumsIL-2R was gradualy decreased with being treated.After treatment (in remission),the sIL-2Rwas obviously lower than that of the before or the intermitant (p<0.05).Level of serum sIL-2R between the before and control had not significantly(p>0.05).It was also suggested thatnumber of L-CFU has a significant relation to the level of serum sIL-2R (p<0.01,r=0.737). |
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| Keywords: | APL sIL-2R L-CFU RA |
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