左旋氨氯地平对高血压并冠心病患者左室舒张功能的影响

目的探讨左旋氨氯地平对高血压并冠心病患者左室舒张功能的影响。方法选择2008年1月～2009年8月在医院门诊病房治疗的60例原发性高血压患者，随机分为观察组30例和对照组30例，观察组给予左旋左旋氨氯地平25mg／d，对照组给予硝苯地平10mg，2次／d开始，根据患者血压情况每3天增加1次剂量，最大至20mg，2次／d，12周为1个疗程；观察比较两组的降压效果及两组治疗前后左室舒张功能的变化。结果两组患者的收缩压和舒张压治疗后均较治疗前显著下降（P〈0．05），且治疗后观察组对照组相比，降压效果经统计学分析，差异有显著性（P〈0．01）。两组治疗前差异无显著性，治疗后，观察组E峰、A峰、EDC、E／A与治疗前比较，经统计学分析，具有统计学意义（P〈0．05），与对照组比较，经统计学分析，也具有统计学意义（P〈0．05）。结论左旋氨氯地平对高血压并冠心病患者左室舒张功能的改变明显，能够达到减少高血压患者心、脑、肾血管并发症的发生、提高人们生活质量的目的，疗效确切、效价比高、是较理想的降压药物。

L - amlodipine on hypertension and coronary heart disease in patients with left ventricular diastolic function

Objective To investigate the L -amlodipine on coronary heart disease in patients with hypertension and left ventricular diastolic function. Methods From January 2008 to August 2009 out - patient wards at the hospital treated 60 patients with essential hypertension were randomly divided into two groups and a control group of 30 cases, observation group was given L - L - amlodipine 25 mg/d, control group was given nifedipine 10 mg,2 times/day beginning, according to the pa- tients every 3 days to increase blood pressure in a dose,to a maximum of 20 mg,2 times / day. 12 weeks for a course of treat- ment; Observation and comparison of the antihypertensive effect and the two groups before and after treatment of left ventricular diastolic function changes. Results The results of two groups of patients with systolic and diastolic blood pressure than those before treatment after treatment significantly decreased （ P 〈 0. 05 ）, and the observation group after treatment compared with the control group, antihypertensive effect through statistical analysis, the difference was significant （P 〈 0. 01 ）. The two groups before treatment was no significant difference in treatment, the observation group E peak, A peak, EDC, E/A before treatment, after statistical analysis, with statistical significance （ P 〈 0. 01 ）, compared with the control group, After statistical analysis, but also statistically significant （ P 〈 0.05 ）. Conclusion L - amlodipine on hypertension and left ventricular diastolic function in patients with coronary heart disease changed significantly,can achieve Reduce high blood pressure in patients with heart,brain and kidney vascular complications and improve people＇s quality of life for the purpose of curative effect,effective bid was high, is an ideal antihypertensive drugs.