不同年龄慢性HBV感染者HBeAg定量与HBVDNA载量关系探讨

探讨不同年龄组慢性HBV感染者HBeAg定量与HBVDNA载量的关系。采用电化学发光法和实时荧光定量聚合酶链反应（FQ—PCR）分别测定1039例慢性HBV感染者血清中HBeAg定量和HBVDNA载量。按≤20、21～40、41～60、≥61岁分成四个年龄组，对结果进行年龄组间比较。结果表明，随着年龄的升高，HBeAg阳性率逐渐降低，HBVDNA阳性率变化不明显。≤20年龄组HBVDNA载量显著高于其他三个年龄组（P〈0．01），而其他三个年龄组间HBVDNA载量无显著差异（P〉0．05）。HBeAg定量与HBVDNA载量（对数）相关性随着年龄的升高而降低。由此可见，不同年龄组HBeAg定量与HBVDNA载量（对数）相关性不同，两者相关性随着年龄的升高而降低。

Correlation between HBeAg quantity and EIBV DNA capacities in different age patients with chronic hepatitis B virus infection

To explore the correlation between HBeAg quantity and HBV DNA capacities in different age groups patients with chronic hepatitis B virus infection. The serum HBeAg quantity and HBV DNA capacities in 1039 patients with chronic hepatitis B virus infection were detected by electrochemiluminescence technique and real - time fluorescent quantitative PCR. Patiens were divided according to the age from 0 to 20,21 to 40,41 to 60, and over 60 years old. The results were compared among different age groups. The results showed that with the increase of age,the positive rate of HBeAg decreased gradu- ally ,while HBV DNA positive rate did not change obviously. HBV DNA capacities of the age group lower than 20 were significant higher than the other three age groups （P 〈 0.01 ）. And HBV DNA capacities of the other three age groups has no significant difference（ P 〉 0.05 ）. The correlation between HBeAg quantity and HBV DNA capacities （log） decreased gradually with increasing age. Therefore,the correlation between HBeAg quantity and HBV DNA capacities （log）was different in four age groups which decreased with increasing age.