紫杉醇联合静脉和腹腔灌注顺铂治疗晚期卵巢癌的临床评价

目的：评价紫杉醇联合静脉和腹腔灌注顺铂治疗晚期卵巢癌的疗效。方法50例晚期卵巢癌肿瘤患者，随机分成治疗组（IP＋IV组：静脉和腹腔运用顺铂联合紫杉醇静脉治疗双途径治疗）28例和对照组（IV组：顺铂联合紫杉醇单纯静脉治疗）22例。结果治疗组有效率85.7%，对照组有效率72.7%，差异具有统计学意义（P〈0.05）。全身毒性反应主要为消化道反应、肾毒性、血液毒性和神经毒性，全身毒性治疗组较对照组略低。结论治疗组较对照组治疗晚期卵巢癌疗效更高，毒性反应可以耐受，腹腔化疗应用于晚期卵巢癌是一种合理而可行的治疗模式。

Effect of paclitaxel combined with vein and abdominal cavity perfusion of cisplatin in the treatment of advanced ovarian cancer

Objective To observe the effect of paclitaxel combined vein and abdominal cavity perfusion of cisplatin in the treatment of advanced ovarian cancer.Methods 50 cases of advanced ovarian cancer were treated, 28 patients received IP＋IV regimen（CDDP intraperitoneal and iv＋Taxol iv）and 22 patients received IV regimen（CDDP iv＋Taxol iv）.Results In IP＋IV group,the response rate was 85.7%. In IV group the response rate was 72.7%. The efficacy was statistically significant （P〈0.05）. The main systematic toxicity were gastrointestinal reaction, nephro-toxicity, myelo-suppression and neurotoxicity. The systematic toxicity of IV was a little more than IP＋IV, but the local toxicity is on the contrary. The efficacy was not statistically significant（P＆gt;0.05）.Conclusion IP＋IV regimen are more effective than IV regime to patients with advanced ovarian cancer. The toxicity can be tolerated. Intraperitoneal chemotherapy can be applied to advanced ovarian cancer.