Drinking in water deprived rats after combined central angiotensin receptor and converting enzyme blockade. |
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Authors: | W B Severs P Klase |
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Affiliation: | Department of Pharmacology, The Milton S. Hershey Medical Center The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA |
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Abstract: | Saralasin, an angiotensin II receptor antagonist, is ineffective in reducing drinking after water-deprivation (WD). Angiotensin III has considerable dipsogenic potency. It may be formed without angiotensin II as an intermediate. To clarify whether angiotensin III formation masks a role for angiotensin in WD, 48 hr WD rats were infused via a lateral cerebroventricle with a) CSF, b) Saralasin, c) SQ 20,881, a converting enzyme inhibitor, or d) Saralasin + SQ. No drug effect on drinking was observed. The results demonstrate that angiotensin III is not required for WD drinking. |
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Keywords: | Angiotensin-CNS Angiotensin III Saralasin Converting enzyme |
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