外周血干细胞移植治疗血液肿瘤283例临床观察

目的 观察外周血干细胞移植(PBSCT)治疗血液肿瘤临床疗效.方法 自2001年3月～2007年4月,对283例血液肿瘤患者施行外周血干细胞移植,其中自体移植231例,异基因移植52例,观察其临床疗效和并发症.结果 除1例ALL外,230例患者行自体外周血干细胞移植后造血功能均快速重建.异基因移植中急性移植物抗宿主病发生率23.1%,慢性移植物抗宿主病发生率21.2%,其中局限型占15.4%;9例患者于移植后1 ～16个月分别死于移植物抗宿主病、感染和疾病复发或进展,35例患者已无病存活3～46个月.结论 外周血干细胞移植是治疗血液肿瘤的有效方法,依据患者疾病诊断、年龄、身体状况、供者情况选择移植方式.

Clinical analysis on peripheral blood stem cell transplantation for hematologic malignancies in 283 cases

Objective To evaluate the therapeutic effect of peripheral blood stem cell transplantation(PBSCT) for hematologic malignancies.Methods Two hundred and eighty-three patients with hematologic malignancies were included in PBSCT(allogenetic PBSCT in 52 patients,autologous PBSCT in 231 patients) from March 2001 to April 2007,then,the therapeutic effect and complication were oberserved,respectively.Results Hematopoieteic reconstitution was quickly obtained after autologous PBSCT in 230 patients except for one case with ALL.The incidence rate of acute GVHD was 23.1%,and chronic GVHD was 21.2%,and limited GVHD was 15.4%.Nine patients died of GVHD,infection,disease relapse or development from 1 to 16 months,and thirty-five patients were disease-free survival(DFS) from 3 to 46 months.Conclusion PBSCT is effective for the treatment of hematologic malignancies,and it is strongly suggested to select suitable mode of transplantation on account of the diagnose of disease,age and physiclal status of patient and the condition of donor.