| 常用非典型抗精神病药物治疗精神分裂症的药物经济学分析 |
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| 引用本文： | 韩萍,周东升,沃联群.常用非典型抗精神病药物治疗精神分裂症的药物经济学分析[J].中国现代医生,2011,49(31):118-120. |
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| 作者姓名： | 韩萍 周东升 沃联群 |
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| 作者单位： | 1. 宁波市康宁医院,浙江宁波,315201
2. 浙江省医药高等专科学校,浙江宁波,315100 |
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| 基金项目： | 浙江省宁波市医疗卫生重点学科建设计划 |
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| 摘 要： | 目的评价常用非典型抗精神病药物治疗精神分裂症的经济学。方法单一抗精神病药物治疗的患者300例人组，计算治疗期间的直接成本，包括药费、挂号费、检查费、住院费、非医疗费。并以阳性与阴性症状量表评分减少量评价药物治疗疗效。结果289例患者完成研究，各组药物疗效差异无统计学意义；以氯氮平为参照，增量成本-效果比依次为利培酮（391．84）、阿立哌唑（1026．64）、齐拉西酮（1178．16）、喹硫平（2072．38）、奥氮平（2250．95）o结论氯氮平最具经济性，利培酮价格较低，成本-效果比和增量成本-效果比都最低。
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| 关 键 词： | 精神分裂症 非典型抗精神病药物 最小成本分析 成本效果分析 药物经济学 |
Pharmacoeconomic Analysis of Non-classical Antipsychotic Drugs Commonly Used for Schizophrenia |
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| Authors: | HAN Ping ZHOU Dongsheng WO Lianqun |
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| Institution: | 1.Ningbo City Kangning Hospital in Zhejiang Province, Ningbo 315201, China; 2.Zhejiang Pharmacoeconomic College in Zhejiang Province, Ningbo 315100, China) |
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| Abstract: | Objective To compare the efficiency and the costs of Non-classical Antipsychotic Drugs commonly used for Schizophrenia. Methods A total of 300 patients with schizophrenia were randomly assigned to receive group risperidone, group quetiapine, group olanzapine and group ziprasidone. The therapeutic efficacies and adverse drug reactions （ ADR ） were monitored and cost-effectiveness Analysis were performed. Results All 289 patients completed the study. To clozapine as a reference, the incremental cost-effectiveness ratio were risperidone （ 391.84 ）, aripiprazole （ 1026.64 ）, ziprasidone （ 1178.16 ）, quetiapine （ 2072.38 ）, olanzapine （ 2250.95 ）. Conclusion Risperidone＇ s price is lower, the cost-effectiveness and incremental cost -effectiveness ratio is the lowest. |
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| Keywords: | Schizophrenia Non-classical antipsychotic drugs Cost-minimization cost-effectiveness analysis Pharmacoeconomic |
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