IRF变化对恶性肿瘤化疗的意义

目的通过了解恶性肿瘤患者化疗过程IRF及相关参数的变化，确定反映骨髓造血功能更加灵敏的指标。方法采用SysmexXE-2100全自动血细胞分析仪对20例恶性肿瘤患者化疗前后外周血中白细胞、网织红细胞绝对数、高荧光强度网织红细胞百分数（HFR％）、中荧光强度网织红细胞百分数（MFR％）和低荧光强度网织红细胞百分数（LFR％）进行检测。结果在恶性肿瘤化疗过程中未成熟网织红细胞分数（IRF）降低较白细胞早2．2d，其升高较白细胞早2．9d（P〈0．05）。结论IRF在反映骨髓造血功能时比白细胞更灵敏，可作为恶性肿瘤患者疗效监测的有效手段之一。

The Significance of IRF Changes for Chemotherapy of Malignant Tumor

Objctive To determine the more sensitive index of reflecting hematopoietic function of bone marrow through the process of IRF chemotherapy in patients with malignant tumors and the change of related parameters. Methods The peripheral blood leukocytes, reticulocyte counts, hyperfluorescence （ HFR% ） moderate fluorescence （ MFR% ） and hypofluorescence （ LFR% ） reticuloeyte percentage were detected for 20 patients with malignant tumors anterior-posterior chemotherapy by the Sysmex XE-2100 automatic blood cell analyzer. Results During the process of chemotherapy with malignant tumors, the immature reticulocyte fractions （ IRF ） reduce 2.2 days earlier and set up 2.9 days earlier than the white blood cell （P 〈 0.05 ）. Conclusion IRF is more sensitive than white blood cell in reflecting the hematopoietic function of bone marrow, so it can be used as the effective means of monitoring the therapeutic effect for the patients with malignant tumor.