帕瑞昔布钠联合丙泊酚用于全麻患者苏醒期躁动的临床观察

目的观察帕瑞昔布钠联合丙泊酚治疗全麻患者苏醒期躁动的疗效。方法全麻拔管后出现苏醒期躁动的90例患者随机分为三组：帕瑞昔布加丙泊酚组（A组）、芬太尼加丙泊酚组（B组）、曲马多加丙泊酚组（c组），每组30例，分别静脉注射帕瑞昔布钠40mg＋丙泊酚lmg／kg、芬太尼1μg／kg＋丙泊酚1mg／kg、曲马多1mg／kg＋丙泊酚1mg／kg进行治疗。观察三组药物治疗苏醒期躁动的疗效、用药前后VAS评分及Ramsay镇静评分、苏醒时间以及药物的不良反应。结果A、B两组治躁动的有效率高于C组（P〈0．05）；与用药前比较，三组患者用药后VAS评分均降低（P〈0．05），C组VAS评分高于A、B两组；Ramsay镇静评分均升高，B组Ramsay镇静评分高于A、C两组（P〈0．05）；B组苏醒时间较长。结论帕瑞昔布钠联合丙泊酚是治疗苏醒期躁动较为安全有效的药物组合，芬太尼加丙泊酚效果较好，但可出现一过性呼吸抑制，且苏醒时间较长，而曲马多加丙泊酚治疗效果欠佳。

Clinical Observation on Parecoxib Sodium with Propofl Treatment Used for Sodium General Patients Waking Restless

Objective To observe the clinical effect of the Parecoxib sodium with Propofl treatment in postoperative agitation in adult patients after general anesthesia. Methods General drawing tube method appeared after awakening period restless the 90 patients were randomly divided into three groups ： Parecoxib sodium with Propofl （ group A ） and fentanyl with Propofl （ group B ）, Tramadol with Propofl （ group C ）, each group of 30 cases, intravenous Parecoxib sodium 40mg＋ Propofl1mg/kg, Fentanyl 1 μ g/kg＋Propofl lmg/ kg, Tramadollmg/kg＋Propofl lmg/kg for treatment. Observed three groups of drug treatment of awakening the curative effect of drug, restless and VAS score and the Ramsay calm score, round and drug adverse reaction time. Results A and B group to restless the efficient than C group （ P 〈 0.05 ） ; And drug use, three groups were compared before when the drug VAS scores were lower（ P 〈 0.05 ）, group C VAS was rating higher than A, B group; Ramsay calm scores were increased, group B Ramsay calm was rating higher than A, C group （P 〈 0.05 ） ; Group B revive the time was long. Conclusion Parecoxib sodium add Propofl is sodium tabor treatment of a safe and effective waking restless combination of drugs, fentanyl add Propofl has a better effect, but there may be a transient respiratory inhibition, and time is long, and the Tramadol add Propofl is inefficient.