伴有复杂核型的慢性粒细胞白血病17例分析

目的探讨慢性粒细胞白血病（CML）患者细胞遗传学改变和预后的关系。方法通过短期培养法和直接法对114例慢性粒细胞白血病患者进行染色体分析，选取其中17例复杂核型表现者进行结果分析。结果14．9％的Ph＋患者（17／114）出现额外染色体，加速期和急变期额外染色体的检出率明显高于慢性期（x2=15．982，P〈0．01）。额外染色体多见于CML急变期。结论CML患者病程中继发额外染色体的异常改变与其病程进展密切相关，染色体核型分析对CML的诊断及预后判断具有重要意义。

Chronic Myelocytic Leukemia with Complex Karyotype: An Analysis of 17 Cases

Objective To study the relationship beween cytogenetic change and the prognosin in patients with chronic myelocytic leukemia, （ CML ）. Methods The karyotype analysis of nuclear cells of bone marrow in 114 cases were performed by short culture and direct preparation and of-which 17 cases w ith complex chromosome abnormalities （ CCAs ） were analysed. Results Extra chromosome changes were demonst rated in 14.9 % of classical Ph cases. The detection of extra chromosome in AP （ accelerated phase ） and BP （ blast crisis phase ） was higher than that in CP （ chronic phase ） （ X^2 =15.982 ） , many abnormal clones were seen simultaneously in BP patients. Conclusion There is a close correlation between extra chromosome changes and the progress of CML. Chromosome karyotype analysis is important in the diagnosis and prediction the prognosis of CML.