伴有复杂核型的慢性粒细胞白血病17例分析 |
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引用本文: | 安利,朱琳,王晓敏.伴有复杂核型的慢性粒细胞白血病17例分析[J].中国现代医生,2011,49(33):122-123. |
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作者姓名: | 安利 朱琳 王晓敏 |
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作者单位: | 新疆维吾尔自治区人民医院血液病科,新疆乌鲁木齐,830001 |
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摘 要: | 目的探讨慢性粒细胞白血病(CML)患者细胞遗传学改变和预后的关系。方法通过短期培养法和直接法对114例慢性粒细胞白血病患者进行染色体分析,选取其中17例复杂核型表现者进行结果分析。结果14.9%的Ph+患者(17/114)出现额外染色体,加速期和急变期额外染色体的检出率明显高于慢性期(x2=15.982,P〈0.01)。额外染色体多见于CML急变期。结论CML患者病程中继发额外染色体的异常改变与其病程进展密切相关,染色体核型分析对CML的诊断及预后判断具有重要意义。
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关 键 词: | 慢性粒细胞性白血病 复杂核型 |
Chronic Myelocytic Leukemia with Complex Karyotype: An Analysis of 17 Cases |
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Authors: | AN Li ZHU Lin WANG Xiaomin |
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Institution: | (Department of Hematology, the People' s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China) |
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Abstract: | Objective To study the relationship beween cytogenetic change and the prognosin in patients with chronic myelocytic leukemia, ( CML ). Methods The karyotype analysis of nuclear cells of bone marrow in 114 cases were performed by short culture and direct preparation and of-which 17 cases w ith complex chromosome abnormalities ( CCAs ) were analysed. Results Extra chromosome changes were demonst rated in 14.9 % of classical Ph cases. The detection of extra chromosome in AP ( accelerated phase ) and BP ( blast crisis phase ) was higher than that in CP ( chronic phase ) ( X^2 =15.982 ) , many abnormal clones were seen simultaneously in BP patients. Conclusion There is a close correlation between extra chromosome changes and the progress of CML. Chromosome karyotype analysis is important in the diagnosis and prediction the prognosis of CML. |
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Keywords: | Chronic myeloeytic leukemia Complex chromosome aberration |
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