| 替米沙坦对2型糖尿病合并高血压患者胰岛素抵抗及APN的影响 |
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| 引用本文： | 李运潮,王冰洁,朱应斌.替米沙坦对2型糖尿病合并高血压患者胰岛素抵抗及APN的影响[J].中国现代医生,2011,49(32):60-61,63. |
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| 作者姓名： | 李运潮 王冰洁 朱应斌 |
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| 作者单位： | 浙江省文成县人民医院内分泌科,浙江文成,325300 |
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| 摘 要： | 目的探讨替米沙坦对2型糖尿病合并高血压患者胰岛素抵抗及APN的影响。方法将80例高血压合并2型糖尿病确诊患者随机分为替米沙坦组和对照组，每组40例。在口服降血糖基础上，替米沙坦组给予替米沙坦片治疗；对照组给予氨氯地平片治疗。结果所有患者在治疗10周后血压均达到140／90mmHg以下，治疗10周后两组SBP、DBP比较，无黟著性差异（P〉0．05o治疗前两组FBS、Fins、HOMA—IR、APN比较无显著性差异（P〉0．05）。治疗10周后，替米沙坦组HOMA—IR较对照组明显降低（P〈0．05），外周血APN含量较对照组明显升高（P〈0．05）。结论采用替米沙坦治疗2型糖尿病合并高血压患者，可以显著改善患者的胰岛素抵抗，提高患者血循环中APN含量，对减少患者远期并发症、改善患者的预后有益，值得临床关注。
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| 关 键 词： | 2型糖尿病 高血压病 替米沙坦 胰岛素抵抗 脂联素 |
The Impact of Telmisartan on Insulin Resistance and Adiponection(APN)in Patients with Hypertension and Accompanied with Type 2 Diabetes |
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| Authors: | LI Yunchao WANG Bingjie ZHU Yingbin |
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| Institution: | LI Yunchao WANG Bingjie ZHU Yingbin Department of Endocrinology,Wencheng County People's Hospital in Zhejiang Province,Wencheng 325300,China |
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| Abstract: | Objective To investigate the impact of telmisartan on insulin resistance and adiponection(APN) in those patients with hypertension and accompanied with type 2 diabetes.Methods A total of 80 patients diagnosed with hypertension and type 2 diabetes were randomly divided into the telmisartan and control groups,with 40 cases in each group.Based on the oral glucose-lowering agents,telmisartan was added in the telmisartan group,while amlodipine was added in the control group.Results In all these patients,the bloo... |
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| Keywords: | Type 2 diabetes Hypertension Telmisartan Insulin resistance Adiponectin |
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