高嘌呤饮食的2型糖尿病患者下肢血管病变危险因素的临床研究

目的 探讨高嘌呤饮食的2型糖尿病（T2DM）患者下肢血管病变的危险凶素。方法 将高嘌呤饮食的T2DM患者分为下肢血管病变组和对照组，比较两组性别、吸烟、高血压、体重指数、血糖、血脂、血尿酸和C反应蛋白等下肢血管病变危险因素的差异；然后将踝肱比（ABI）与上述指标进行单因素相关分析；最后以有无下肢血管病变为因变量，以单因素相关分析所得的危险因素为自变量，进行多因素Logistic回归分析，探讨T2DM患者下肢血管病变的危险因素。结果 下肢血管病变组高血压的患病率、收缩压、病程、空腹血糖、血尿酸和C反应蛋白等均高于对照组，差异有统计学意义（P〈0.05）。年龄、糖尿病病程、收缩压、血尿酸和C反应蛋白与ABI负相关（P〈O.05）。Logistic回归分析显示，收缩压、糖尿病病程、血尿酸和C反应蛋白是下肢血管病变的独立危险因素（P〈0.05）。结论 糖尿病病程、收缩压、血尿酸和C反应蛋白是T2DM患者下肢血管病变的独立危险因素。高嘌呤饮食并未增加T2DM患者下肢血管病变的患病率。

The Clinical Study of the Risk Factors of Type 2 Diabetes Mellitus with Vascular Lesions of Lower Extremities

Objective To explore the risk factors of the Type 2 Diabetes Mellitus（T2DM） patients with vascular lesions of lower extremities. Methods All 86 T2DM patients who had suffered vascular lesions of lower extremities were divided into the observed group,86 patients who had not suffered vascular lesions of lower extremities were divided into the compared group. We detected the following parameters ： cholesterol, glycerin trilaurate, high density lipoprotein, blood uric acid, fasting blood-glucose, body mass index, course of disease,blood pressure and the C reaction protein（CRP）. Compared the difference of these parameters of both groups. Correlation analysis and logistic regression analysis were used to explore the risk factors of the T2DM patients with vascular lesions of lower extremities. Results The rate of hypertension, systolic pressure,fasting blood-glucose,the course of disease,blood uric acid and CRP were significantly higher in the observed group than those in the compared group. The course of disease,systolic pressure,blood uric acid and CRP positively correlate with vascular lesions of lower extremities in observed group according to both correlation analysis and logistic regression analysis. Conclusion The course of disease, systolic pressure,blood uric acid and CRP are independent risk factors of vascular lesions of lower extremities in patients of T2DM, and getting too much food with purine did not increase the rate of vascular lesions of lower extremities.