慢性阻塞性肺疾病患者抑郁障碍及相关因素分析

目的了解慢性阻塞性肺疾病患者抑郁状况并探讨其相关因素。方法本研究运用抑郁自评量表（SDS）及自行设计的相关因素调查表对120例缓解期慢性阻塞性肺疾病患者进行抑郁状况调查。结果54．2％的慢性阻塞性肺疾病患者存在不同程度的抑郁障碍，COPD并发抑郁组肺功能（FEV1、FEV1／FVC）、动脉血气分析（PaO2、PaC02）与无并发抑郁组比较，两组间均有显著性差异（P〈0．01）。相关回归分析：缓解期COPD患者的SDS评分与肺功能（FEVl、FEVl／FVC）、动脉血PaO2呈负相关（r=-0．325，-0．364，-0．253）；与动脉血PaC02、病程、经济负担呈正相关（r=0．265，0．216，0．227）。结论慢性阻塞性肺疾病患者存在不同程度抑郁障碍，应针对性地开展干预措施降低患者的抑郁状态。

Analyses of Related Factors and the Depressive Disorder in Patients of Chronic Obstructive Pulmonary Disease

Objective To explore the relevant factors and to understand the depressive disorder in patients of chronic obstructive pulmonary disease. Methods All 120 cases of patients with chronic obstructive pulmonary disease in lysis period were assessed by the Self-rating Depression Scale （ SDS ） and the self-designed questionnaire related factors for the depression survey. Results 54.2% of chronic obstructive pulmonary disease patients have different degrees of depression. There were significantly differences （ P 〈 0.01 ） in the lung function （ FEV1, FEV1/FVC ）and the arterial blood gas analysis （ PaO2, PaCO2 ）between the concurrent depression group and the non-concurrent depression group in patients of chronic obstructive pulmonary disease. Regression analysis showed that the SDS score was negatively correlated with the lung function （ FEV1, FEV1/FVC ） and the arterial blood gas analysis （ PaO2 ）on patients with COPD in lysis period （r=-0.325, -0.364, -0.253 ）. But it was positively correlated with the arterial blood PaCO2, course of disease and economic burden （r=0.265,0.216,0.227）. Conclusion Chronic obstructive pulmonary disease patients have varying degrees of depression. Targeted interventions should be carried out to reduce depression in patients.