神经精神狼疮相关的自身抗体

目前，神经精神狼疮的诊断仍是临床难题，本文对与NPSLE相关的自身抗体进行综述，以期有助于NPSLE的发病机制和诊断的研究。抗内皮细胞抗体可引起内皮细胞损伤，导致颅内小血管病变，因此NPSLE可能出现相应的临床表现。在NPSLE中，抗胶质原纤维酸性蛋白抗体可能改变了胶质细胞膜电流而致病。抗N-甲基-D-天（门）冬氨酸（NMDA）受体抗体在NPSLE患者中可能通过血脑屏障，通过抗原抗体反应引起神经元凋亡而致病。抗磷酸丙糖异构酶抗体可与神经元相关蛋白结合引起神经元凋亡，并通过激活补体和巨噬细胞引起神经元和轴突变性，可能导致NPSLE发病。抗微管相关蛋白-2抗体可能是NPSLE的免疫标记物。

Autoantibodies of Neuropsychiatric Lupus Erythematosus

Now,diagnosis of neuropsychiatric systemic lupus erythematosus （NPSLE） is also clinical challenge. The article is a summary that is about of autoantibodies of NPSLE. It may be help to study the diagnosis and pathogenesis of NPSLE. Because anti-endothelial cell antibodies injure small vessels in the brain,NPSLE can be some of clinical manifestations. Anti-glial fibrillary acidic pro tein antibodies can cause NPSLE by change of glial cell membrane potentials. It may be a pathogenesis of NPSLE that anti-N-methyl-D-aspartate receptor antibodies can canes apoptosis of neurons by antigen antibody reaction. Anti-triosephosphate isomerase antibodies associated with neuronal proteins cause neuronal apoptosis,and through activation of complement and maeroghase cause neuronal and axonal degeneration,which may lead to NPSLE. Anti-microtubule-associated protein-2 antibodies may be NPSLE immune markers.