盐酸多奈哌齐治疗阿尔茨海默病的临床效果观察

目的探讨盐酸多奈哌齐治疗阿尔茨海默病（Alzheimer disease，AD）的临床效果。方法对120例AD患者随机分为观察组和对照组，每组各60例，对照组采用脑复康治疗，观察者在对照组的基础上采用盐酸多奈哌齐治疗，两组均以12周为一个疗程。采用简易智力状态检查量表（MMSE）、日常生活能力量表（ADL）、AD评定量表认知部分次级量表（ADAS—cog）评价两组患者的治疗效果。结果观察组治疗后MMSE、ADL及ADAS—cog评分改善程度显著优于对照组（P〈0．05）。且两组患者的不良反应均可耐受，未中断治疗。结论盐酸多奈哌齐治疗AD疗效满意，能显著改善患者的认知能力和日常生活能力，且耐受性好。

Clinical Observation of Effect of Donepezil Hydrochloride in Treating Alzheimer's Disease

Objective To explore the clinical effect of donepezil HC1 in treating Alzheimer ＇ s disease （ AD ）. Methods All 120 AD patients were randomly divided into treatment group and control group, and each group of 60 cases. Treatment group using brain rehabilitation therapy, the observer were used donepezil HC1 to treat on the basis of the control group. Both groups were given 12 weeks for a period of treatment. To evaluate the therapeutic effect of two groups of patients with Mini-mental state examination （ MMSE ）, Activities of daily living （ ADL ） and Alzheimer＇ s disease assessment scale-Cognitive portion （ ADAS-cog ）. Results After treatment, patient＇ s MMSE score, ADL score and AI）AS-cog score were improved more greatly than the control group （P 〈 0.05 ）, and two groups patients did not interrupt treatment. Conclusion The effects of using donepezil HC1 to treat Alzheimer＇ s disease is satisfactory, and it can effectively improve cognition, activities of daily living and well tolerated.