甲磺酸多沙唑嗪片治疗轻中度原发性高血压的临床试验

探讨甲磺酸多沙唑嗪片对轻、中度原发性高血压的疗效和艇。方法：对８０例患者进行随机、双盲和前瞻性研究。４０例患者随机分别口服多沙唑嗪（多沙唑嗪组）或特性唑嗪（对照组）,均服药８周,另４０例口服多沙唑嗪（开放组）,其中１０例口服多沙唑嗪６个月。结果试验组和对照组用药后血压均明显下降,在第４周下降到最大值并稳定到试验结束,心率均略加快,但无统计学意义。试验组和对照组降压总有效率分别为９５．０％和７３．０

Effects of doxazosin in treatment of mild to moderate essential hypertension

Objective: To investigate the effect of doxazosin on mild to moderate essential hypertension. Methods: A prospective, randomized, double blind study was carried out in 80 patients with hypertension. Forty patients were randomly given doxazosin (doxazosin group) or terazosin (control group) for 8 weeks. The others 40 were given doxazosin (open group), 10 of them for 6 months. Results: BP decreased significantly after administration of both doxazosin and terazosin, and reached its peak at week 4. The effect continued at the end of experiment. HR was slightly increased. In open group, the results was similar and the total effective rate was 90.0%. There were no significant changes in liver and renal functions and electrocardiography. The incidence of adverse effects like dizziness, palpitation and somnolence in doxazosin group was 30.0% . No significant difference between doxazosin and control group was found. Conclusion: Doxazosin has stable hypotensive effect and the patients compliance is good.