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| 脂联素基因+45位T/G多态性与2型糖尿病遗传易感性的相关性 | |
| 引用本文： | 魏颖丽,何兰杰,霍正浩,赵巍.脂联素基因+45位T/G多态性与2型糖尿病遗传易感性的相关性[J].基础医学与临床,2008,28(9):940-943. |
| 作者姓名： | 魏颖丽 何兰杰 霍正浩 赵巍 |
| 作者单位： | 1. 浙江武警总队医院杭州医院,浙江,杭州,310000 2. 宁夏医学院,附属医院内分泌科,宁夏,银川,750004 3. 宁夏医学院医学遗传学与细胞生物学教研室,宁夏,银川,750004 |
| 基金项目： | 国家自然科学基金，宁夏自然科学基金 |
| 摘 要： | 目的 研究脂联素基因单核苷酸多态性(SNP)45(T/G)位点与宁夏汉族人群2型糖尿病之间的关系.方法 100例2型糖尿病患者和101例正常对照者,采用聚合酶链式反应--限制性内切酶长度多态性(PCR-RFLP)技术,对脂联素基因SNP45多态性位点进行基因分型,同时测定代谢参数.结果 2型糖尿病组SNP45位点GG基因型频率和G等位基因频率均高于正常对照组(P＜0.05).结论 脂联素基因的SNP45多态性位点与宁夏汉族人群中2型糖尿病相关;GG基因型者具有2型糖尿病高易感性. |
| 关 键 词： | 2型糖尿病 脂联素 基因 单核苷酸多态性 遗传易感性 |
| 收稿时间： | 2006-4-5 |
| 修稿时间： | 2008-1-30 |
SNP 45(T/G)of adiponectin gene polymorphism and genetic susceptibility to type 2 diabetes mellitus |
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| WEI Ying-li,HE Lan-jie,HUO Zheng-hao,ZHAO Wei.SNP 45(T/G)of adiponectin gene polymorphism and genetic susceptibility to type 2 diabetes mellitus[J].Basic Medical Sciences and Clinics,2008,28(9):940-943. | |
| Authors: | WEI Ying-li HE Lan-jie HUO Zheng-hao ZHAO Wei |
| Abstract: | Objective To investigate the relation of single nucleotide polymorphisms (SNP)45T/G the adiponectin gene with type 2 diabetes of Han nationality in Ningxia.Methods PCR-RFLP method was used to identify the distribution of alleles and genotypes frequencies of SNP45T/G polymorphisms in adiponectin gene in 100 type 2 diabetic patients and 101 normal subjects.Results The distribution of genotypes and alleles frequencies of the SNP45 polymorphisms were significantly different (GG genotype:13% vs 3%,P<0.05;G allele;76% vs 24%, P<0.05).Conclusion SNP45 in adiponectin gene was related to type 2 diabetes of Han nationality in Ningxia. Individuals with SNP45 GG genotype of adiponectin gene have high susceptibility to type 2 diabetes. |
| Keywords: | type2 diabetes adiponectin gene single nucleotide polymorphisms genetic susceptibility |
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