| 新诊断2型糖尿病合并非酒精性脂肪肝患者 下肢动脉粥样硬化的临床分析 |
| |
| 引用本文： | 张晓菲,陈燕铭,孙艳,王曼曼,何圣清,舒冏,张国超,曾龙驿.新诊断2型糖尿病合并非酒精性脂肪肝患者 下肢动脉粥样硬化的临床分析[J].中山大学学报(医学科学版),2010,31(1). |
| |
| 作者姓名： | 张晓菲 陈燕铭 孙艳 王曼曼 何圣清 舒冏 张国超 曾龙驿 |
| |
| 作者单位： | 1. 中山大学附属第三医院,内分泌科,广东 广州 510630
2. 中山大学附属第三医院,内分泌科,广东 广州 510630;中山大学附属第三医院,体检中心,广东 广州 510630;中山大学附属第三医院,特诊中心,广东 广州 510630 |
| |
| 摘 要： | 【目的】 探讨新诊断2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)患者发生下肢动脉粥样硬化的临床特点及危险因素｡ 【方法】 对151例新诊断2型糖尿病住院患者进行回顾性研究｡根据是否合并NAFLD分为A组(合并NAFLD,92例)和B组(无NAFLD,59例),比较两组患者胰岛素抵抗､脂代谢紊乱､下肢动脉粥样硬化程度的差异｡【结果】 92例(60.93%)新诊断住院2型糖尿病患者伴NAFLD,A组有较高的体质量指数､甘油三酯､血尿酸､胰岛素抵抗指数､空腹胰岛素和C肽､餐后2 h胰岛素和C肽水平,及较低的高密度脂蛋白胆固醇和胰岛素敏感指数水平;与B组比较,差异有统计学意义(P < 0.05);两组血糖则无明显差别(P > 0.05)｡101例(66.89%)新诊断住院2型糖尿病患者伴不同程度的下肢动脉血管病变,A组下肢动脉粥样硬化较B组明显增加｡【结论】 新诊断2型糖尿病患者脂肪肝及下肢血管动脉硬化都较高,合并NAFLD的患者发生下肢动脉硬化比不合并NAFLD的患者明显升高,而且下肢动脉硬化病变也更严重｡
|
| 关 键 词： | 2型糖尿病 非酒精性脂肪肝 下肢动脉粥样硬化 胰岛素抵抗 |
| 收稿时间： | 2009-09-13; |
Clinical Investigation of Lower-extremity Arterial Disease in Patients with Newly Diagnosed Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease |
| |
| ZHANG Xiao-fei,CHEN Yan-ming,SUN Yan,WANG Man-man,HE Sheng-qing,SHU Jiong,ZHANG Guo-chao,ZENG Long-yi.Clinical Investigation of Lower-extremity Arterial Disease in Patients with Newly Diagnosed Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease[J].Journal of Sun Yatsen University(Medical Sciences),2010,31(1). |
| |
| Authors: | ZHANG Xiao-fei CHEN Yan-ming SUN Yan WANG Man-man HE Sheng-qing SHU Jiong ZHANG Guo-chao ZENG Long-yi |
| |
| Institution: | ZHANG Xiao-fei1,CHEN Yan-ming1,2,3,SUN Yan1,WANG Man-man1,HE Sheng-qing1,SHU Jiong1,ZHANG Guo-chao1,ZENG Long-yi1 (1.Department of Endocrinology,2.Physical Examination Center,3.VIP Center,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China) |
| |
| Abstract: | Objective] To investigate the clinical characteristics and risk factors of lower-extremity arterial disease in the patients with newly diagnosed type 2 diabetes mellitus combined with nonalcoholic fatty liver disease (NAFLD). Methods] One hundred fifty-one patients were investigated respectively. The patients were divided into two groups (NAFLD-Group and non-NAFLD group) by liver ultrasonography and disease history, then their clinical data were collected and compared in order to find the differences of biochemical indicators and the morbidity of lower-extremity arterial disease between two groups. Results] Ninety-two cases (60.93%) were complicated with NAFLD. NAFLD group had higher levels of fast insulin and C peptide level, postprandial insulin and C peptide level, uric acid, body mass index (BMI), homeostasis model assessment (HOMA-IR) and lower level of high-density lipoprotein cholesterol and insulin sensitive index than those of without NAFLD (P<0.05). One hundred and one cases(66.89%) were complicated with lower-extremity arterial disease. The morbidity of lower-extremity arterial diseases was higher in NAFLD group than that of without NAFLD group (75% vs. 54.24%, P<0.01). Conclusion] Both lower-extremity arterial disease and NAFLD are common complicated with type 2 diabetes. The morbidity of lower-extremity arterial diseases was higher in NAFLD group than that of without NAFLD group. |
| |
| Keywords: | type 2 diabetes mellitus nonalcoholic fatty liver disease lower-extremity arterial disease insulin resistant |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中山大学学报(医学科学版)》浏览原始摘要信息 |
| 点击此处可从《中山大学学报(医学科学版)》下载免费的PDF全文 |
|
