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| 缬昔洛韦的合成 | |
| 引用本文： | 赵吉鑫,石东方,梅之南,曹意斌. 缬昔洛韦的合成[J]. 中国现代应用药学, 1999, 16(1): 32-33 |
| 作者姓名： | 赵吉鑫 石东方 梅之南 曹意斌 |
| 作者单位： | 1. 黄石,435000,湖北黄石市长征制药厂 2. 黄石,湖北黄石卫校药剂科 3. 武汉,430060,湖北医科大学附一院药学部 |
| 摘 要： | 目的；对缬昔洛韦的合成进行了研究。方法：以阿昔洛韦和Ｎ－苄氧羰基－Ｌ－缬氨酸为原料，经酰化，催化氢解反应得到了新型抗疱疹毒药物缬昔洛韦。结果；本品的元素分析，红外，质谱及核磁共振图谱数据与文献报道一致，总收率为４５．２％，结论；采用此法合成缬昔洛韦是可行的，适合于工业生产。 |
| 关 键 词： | 缬昔洛韦 阿昔洛韦 合成 抗病毒药 |
The synthesis of valaciclovir |
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| Zhao Jixing(Zhao JX,Shi Dongfang(Shi DF,Mei Zhinan(Mei ZN,et al. The synthesis of valaciclovir[J]. The Chinese Journal of Modern Applied Pharmacy, 1999, 16(1): 32-33 | |
| Authors: | Zhao Jixing(Zhao JX Shi Dongfang(Shi DF Mei Zhinan(Mei ZN et al |
| Abstract: | OBJECTIVE:The synthesis of valaciclovir was studied in this article.METHODS:This compound was synthesized via acylation and hydrogenization using aciclovir and CBZ-L-valine as meterial.RESULTS:The element analysis,IR,MS and 1HNMR of synthetic product were comformable to the literature,the total yield was 45.2%.CONCLUSION:This synthetic method was available and suitable for industrial manufacture. |
| Keywords: | valaciclovir aciclovir synthesis |
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