抗抑郁治疗对老年不稳定型心绞痛伴抑郁患者近期预后的影响

目的观察抗抑郁治疗对老年不稳定型心绞痛伴抑郁患者近期预后的影响.方法将老年不稳定型心绞痛伴抑郁的患者随机分为抗郁治疗组和对照组各38例,治疗组在常规心脏药物治疗基础上予心理治疗及加服抗抑郁药氟西汀20 mg 1/d,共12周;对照组只给予单纯常规心脏药物治疗.结果治疗组心肌缺血明显改善,心绞痛复发率及发生急性心肌梗死比例低,与对照组比较,差异有显著性(P＜0.05).结论抗抑郁治疗能明显改善不稳定型心绞痛伴抑郁患者的近期预后.

The influence of antidepressive therapy on short-term prognosis in elderly patients with unstable angina and depression

Objective To observe the influence of antidepressive therapy on short-term prognosis in elderly unstable angina pectoris patients with depression. Methods 76 unstable angina pectoris patients were randomed into a therapy group (38) and control group (38). Patients in the therapy group were treated with psychotherapy and administration of antidepressant Fluoxetine (Prozac Eli Lilly, USA) 20mg once a day on the basis of regular cardiac medicine therapy for 12 weeks, Patients in the control group were only treated with regular cardiac medicine therapy. Results Myocardial ischaemia in the therapy group was significantly improved. The recurrence rate of angina pectoris and incidence ratio of acute myocardial infarction in the therapy group were low. There was significant difference in comparison with the control group (P<0.05). Conclusion An tidepression can significantly improve the short-term prognosis in elderly unstable angina pectoris patients.