4种药物防治高原脱适应的对比观察

目的筛选防治高原脱适应的药物品种。方法对驻守海拔5170m一年的57名某部官兵,在返回平原(海拔1400m)前5天随机分为5组,分别口服银杏叶片(12人)、复方红景天胶囊(12人)、刺五加片(11人)、复方党参胶囊(11人)、炒面胶囊(对照组,11人),至返回平原第7天停药,共服药12天。采用高原脱适应症状调查表调查部队返回平原第2天、4天、6天的高原脱适应情况,并计算出每天的总得分。采用二级定量负荷踏阶运动实验评价受试者返回平原第7天的PWC170和台阶指数。结果与对照组比较,复方党参组和复方红景天组高原脱适应症状显著减轻(P<0.01或P<0.05),且复方党参组明显优于银杏叶片组和刺五加组(P<0.05)。与对照组比较,复方党参组和复方红景天组PWC170和台阶指数均显著提高(P<0.05)。结论复方党参胶囊和复方红景天胶囊防治高原脱适应效果较好。

The Contrastive Observation of Four Kinds of Medicine Prevention and treatment De-adaptation to High altitude

Objective: Filtrate medicine of prevention and cure de-adaptation to high altitude. Methods: 57 youths defended at 5170m altitudes for one year were randomly divided into 5 groups before 5 days return plain (1 400m). 12 persons in group 1 took orally gingkgo biloba, 12 persons in group 2 took rhodiola, 11 persons in group 3 took Ciwujiapian, 11 persons in group 4 took compound Dangshen and 12 persons in group 5 took placebo until arrived plain for 1 week. We investigated the symptom of de-adaptation to high altitude with de-adaptation questionary on the 2nd, 4th and 6th day, and counted the sum of score. We evaluated PWC170 and step index by heart rate during a given exercise experiment. Results: Compared with contrast group,the symptom of de-adaptation in compound Dangshen and rhodiola group reduced significantly (P<0.01or P<0.05), and compound Dangshen is preceded than gingkgo biloba and Ciwujiapian(P<0.05). Compared with contrast group,the PWC170 and step index of compound Dangshen and rhodiola group increased significantly(P<0.05) Conclusions: Compound Dangshen and rhodiola are better at prevention and cure de-adaptation to high altitude.