| rhIL-1受体拮抗剂对大鼠肾小球系膜细胞增殖和合成细胞外基质-胶原的影响 |
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| 引用本文： | 刘学辉,杨霁云,马大龙,张英,狄春辉.rhIL-1受体拮抗剂对大鼠肾小球系膜细胞增殖和合成细胞外基质-胶原的影响[J].中华微生物学和免疫学杂志,1995(4). |
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| 作者姓名： | 刘学辉 杨霁云 马大龙 张英 狄春辉 |
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| 作者单位： | 北京医科大学第一临床学院儿科，北京医科大学第一临床学院儿科，北京医科大学免疫研究中心，北京医科大学第一临床学院儿科，北京医科大学免疫研究中心 100034，100034，100034 |
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| 基金项目： | 洛氏基金会中华医学基金(CMB)资助 |
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| 摘 要： | 采用肾小球系膜细胞(GMC)培养、~3H-TdR掺入及羟脯氨酸测定的方法,首次观察了重组人白细胞介素-1受体拮抗剂(rhIL-1Ra)对白细胞介素1β(IL-1β)诱导的大鼠GMC增殖和合成细胞外基质-胶原的影响。结果表明:rhIL-1Ra能拮抗hIL-1β诱导的GMC的增殖和胶原的合成;其拮抗增殖的剂量是rhIL-1β的2～50倍,拮抗胶原合成者为rhIL-1β的25～50倍。提示:rhIL-1Ra有望用于治疗由IL-1参与、介导的以系膜细胞增殖和系膜基质扩大为主要病理改变的肾小球肾炎。
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| 关 键 词： | 系膜细胞 IL-1Ra IL-1β |
EFFECTS OF rhIL-1Ra ON THE PROLIFERATION AND THE SYNTHESIS OF EXTRACELLULAR MATRIX-COLLAGENS IN GLOMERULAR MESANGIAL CELLS (GMC) |
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| Liu Xuehui,Yang Jiyun,Ma Dalong,et al.EFFECTS OF rhIL-1Ra ON THE PROLIFERATION AND THE SYNTHESIS OF EXTRACELLULAR MATRIX-COLLAGENS IN GLOMERULAR MESANGIAL CELLS (GMC)[J].Chinese Journal of Microbiology and Immunology,1995(4). |
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| Authors: | Liu Xuehui Yang Jiyun Ma Dalong |
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| Institution: | Liu Xuehui,Yang Jiyun,Ma Dalong,et al Department of Pediatrics,The First School of Clinical Medicine Beijing Medical University,Beijing 100034 |
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| Abstract: | Using the methods of GMC culture,3H-TdR incorporation and measurement of hydroxyproline.we first observed the effects of rhIL-IRa on the proliferation and the synthesis of extracellular matrix-collagens induced by rhIL-1B in GMC of rats. The results showed that: 1. rhlL-lRa could antagonize the proliferation and collagens synthesis induced by rhIL-l|3. Its dosage that antagonized to the proliferation was 2~50 folds of the rhIL-lB. Its dosage that antagonized to the collagens synthesis was 25~50 folds of the rhIL-lB. It suggests that rhIL-IRa might be used to treat glomeru-lonephritis initiated by IL-1B. |
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