Effects of H1- and H2-antihistamines on platelet-activating factor and bradykinin-induced inflammatory responses in human skin |
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| Authors: | J.E. SANSOM J. BROOKS T.L. BURTON C.B. ARCHER |
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| Affiliation: | Department of Dermatology, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK |
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| Abstract: | Previous studies show that oral antihistamines affect the Weal and flare response to intradermal injections of the inflammatory mediators platelet-activating factor (PAF) and bradykinin (BK). The aim of this study was to compare the effects of terfenadine (an H2-antagonist) and cimetidine (an H2-antagonist) on weal and Hare responses to PAF and BK in healthy non-atopic human volunteers. The effects of doxepin on PAF responses were investigated, as there is evidence that doxepin may have direct anti-PAF ejects in addition to its known antihisiaminic actions. |
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