兔颌面部撞击伤致颅脑损伤后内皮素含量和脑水肿的变化

了解颌面部撞击伤与颅脑损伤的关系，内皮素（ＥＴ）与在颅脑损伤发展过程中的作用。实验兔２５只，分别以平均速度８ｍ／ｓ和３ｍ／ｓ的撞击头致颌面部２，伤后早期观察颌面部和颅脑伤情，分析脑损伤发生条件。取脑组织标本光镜及电镜观察，研究颅脑损伤特点，测定血浆和脑组织中ＥＴ含量及脑含水量。颌面部撞击作国后脑组织病理改变明显，伤后血浆和脑组织匀浆中ＥＴ含量显著提高，出现脑水肿，高速组变化更显著。内皮素含量变化与

ALTERATION OF ENDOTHELIN-1 AND BRAIN WATER CONTENT IN BRAIN INJURY FOLLOWING MAXILLOFACIAL IMPACT INJURY IN RABBIT

Aim to study the role of endothelin(ET)in experimental maxillofacial impact injury with intercurrent brain injury and the relationship between maxillofacial impact injury and brain injury. Twenty five rabbits were subjected to impact in side face with different velocities of average 8m/s and 3m/s. The concentration of ET in plasma and brain tissue plasm and the brain water content was measured at different time points(30min,2h,6h)after maxillofacial impact injury. The pathological changes at every time points were observed under light and electron microscope. The concentration of ET in plasma and brain tissue plasm increased markedly, and brain edema appeared in early period after maxillofacial injury. Maxillofical impact injury with maxillary or mandible fracture may result in brain injury of various grades, and ET is involved in the responsive process following maxillofacial impact injury and is in connection with brain edema.