| 葡萄糖转运蛋白4囊泡运输及相关的临床疾病 |
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| 引用本文： | 陈思聪,江若安,郑筱祥. 葡萄糖转运蛋白4囊泡运输及相关的临床疾病[J]. 国外医学:内科学分册, 2009, 36(10): 606-609 |
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| 作者姓名： | 陈思聪 江若安 郑筱祥 |
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| 作者单位： | [1]浙江大学生物医学工程系,生物医学工程教育部重点实验室,浙江大学玉泉校区,浙江杭州310027 [2]浙江大学医学院临床医学三系,浙江大学华家池校区,浙江杭州310058 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 葡萄糖转运蛋白4（Glut4）是骨骼肌、心肌以及脂肪细胞摄取葡萄糖的重要媒介，它在维持机体糖稳态中起关键作用。因此，对Glut4的囊泡运输及相关蛋白、分子信号转导通路以及相关临床疾病的研究意义重大。本文综述了微管、微丝、分子马达在胰岛素受体细胞Glut4囊泡运输中发挥的作用，及最近报道的一些与Glut4共定位蛋白的特殊作用。此外本文对胰岛素刺激Glut4转运的多条信号通路以及Glut4相关临床疾病也做了详细介绍。
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| 关 键 词： | 葡萄糖转运蛋白4 囊泡运输 细胞骨架 信号通路 临床疾病 |
The vesicle traffic and related clinical diseases of glucose transporter 4 |
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| CHEN Si-cong ,JIANG Ruo-an ,ZHENG Xiao-xiang . College of Biomedical Engineering , Instrument Science,Key Laboratory of Biomedical Engineering of Ministry of Education,Zhejiang University Yuquan Campus,Hangzhou ,China, School of Medicine,Zhejiang University Huajiachi Campus,Hangzhou. The vesicle traffic and related clinical diseases of glucose transporter 4[J]. Foreign Medical Sciences(Section of Internal Medicine), 2009, 36(10): 606-609 |
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| Authors: | CHEN Si-cong JIANG Ruo-an ZHENG Xiao-xiang . College of Biomedical Engineering Instrument Science Key Laboratory of Biomedical Engineering of Ministry of Education Zhejiang University Yuquan Campus Hangzhou China School of Medicine Zhejiang University Huajiachi Campus Hangzhou |
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| Affiliation: | CHEN Si-cong 1,JIANG Ruo-an 2,ZHENG Xiao-xiang 1.1 College of Biomedical Engineering and Instrument Science,Key Laboratory of Biomedical Engineering of Ministry of Education,Zhejiang University Yuquan Campus,Hangzhou 310027,China,2 School of Medicine,Zhejiang University Huajiachi Campus,Hangzhou 310058 |
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| Abstract: | Glucose transporter 4(Glut4) is of great importance as a medium of taking up glucose and in maintaining glucose homeostasis.Thus,studies in the fields of its vesicle traffic,signal pathway and clinical diseases make senses.This article reviewed the effect of microtubule,microfilament and molecular motor in Glut4 vesicle traffic in insulin-responded cells,and noticed some later reports about the proteins co-localized with Glut4.Moreover,this article introduced the signal pathway and related clinical diseases... |
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| Keywords: | Glucose transporter 4 Vesicle traffic Cytoskeleton Signal pathway Clinical diseases |
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