首页 | 本学科首页   官方微博 | 高级检索  
检索        


A hematoporphyrin-based delivery system for drug resistance reversal and tumor ablation
Authors:Yu Ren  Ruirui Wang  Yang Liu  Hua Guo  Xuan Zhou  Xubo Yuan  Chaoyong Liu  Jianguo Tian  Haifang Yin  Yinsong Wang  Ning Zhang
Institution:1. Research Center of Basic Medical Sciences & Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Medical University, Tianjin 300070, PR China;2. School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China;3. Department of Head & Neck, Tianjin Cancer Institute and Hospital, Tianjin 300060, PR China;4. School of Physics, Nankai University, Tianjin 300071, PR China;5. School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin Medical University, Tianjin 300070, PR China
Abstract:Nanotechnology-based drug delivery systems have been intensively investigated, while only a few of them can be used for clinic application. Hematoporphyrin (HP), a major molecule in erythrocyte, has been widely used in photodynamic therapy (PDT). In the present study, polyethylene glycol (PEG) modified hematoporphyrin (HPP)-based nanoparticle system was designed to load doxorubicin (HPPD), in achieving a synergistic effect of chemotherapy and PDT. Herein we presented that HPPD formed narrowly dispersed nanoparticles at 35 ± 2 nm, yielding an enhanced drug release at pH5.8 along with laser radiation. This combined treatment with HPPD and radiation facilitated drug penetration to the nucleus thereby reducing 12-fold decrease in IC50 value and promoting apoptosis in drug-resistant breast cancer cells. Notably, little toxicity was detected with HPP at the cellular level and in animal models. Live animal imaging revealed that HPPD performed ultra high tumor uptake in both mice and marmoset models. Strikingly, intravenous administration of HPPD and radiation on the tumor achieved efficient tumor ablation, without inducing myocardial injury. We report here the development of a biomolecule, HP-based nanoparticle system, which can synergistically yield chemotherapy and PDT.
Keywords:Hematoporphyrin  Doxorubicin  Tumor targeting  Chemotherapy  Photodynamic therapy
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号