| 血清PSA含量及前列腺PSA密度与经直肠超声引导下前列腺穿刺活检诊断前列腺癌的关系 |
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| 引用本文： | 金秋龙,郭建锋,郑凯,顾华芸,严禹,周轶群.血清PSA含量及前列腺PSA密度与经直肠超声引导下前列腺穿刺活检诊断前列腺癌的关系[J].中国介入影像与治疗学,2015,12(10):616-620. |
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| 作者姓名： | 金秋龙 郭建锋 郑凯 顾华芸 严禹 周轶群 |
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| 作者单位： | 南京医科大学附属苏州医院超声科, 江苏 苏州 215001,南京医科大学附属苏州医院超声科, 江苏 苏州 215001,南京医科大学附属苏州医院超声科, 江苏 苏州 215001,南京医科大学附属苏州医院超声科, 江苏 苏州 215001,南京医科大学附属苏州医院超声科, 江苏 苏州 215001,南京医科大学附属苏州医院超声科, 江苏 苏州 215001 |
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| 摘 要： | 目的探讨经直肠超声引导下前列腺穿刺活检术前列腺癌检出率与血清前列腺特异性抗原(PSA)及血清前列腺特异性抗原密度(PSAD)的关系。方法对134例患者行经直肠超声引导下前列腺5区13针系统穿刺活检。根据PSA水平分为PSA≤4ng/ml组(7例)、4ng/mlPSA15ng/ml组(48例)及PSA≥15ng/ml组(79例)。测量并计算前列腺体积(PV)及PSAD,分析前列腺癌检出率及不同PSA、PSAD水平下对前列腺癌的诊断效能。比较前列腺癌与非前列腺癌患者PSA、PV及PSAD的差异。结果前列腺癌总检出率为50.75%(68/134),前列腺患者共68例(前列腺癌组),非前列腺癌患者共66例(非前列腺啊组)。PSA≤4ng/ml、4ng/mlPSA≤15ng/ml及PSA15ng/ml组前列腺癌检出率分别为14.29%(1/7)、20.83%(10/48)及72.15%(57/79),差异有统计学意义(P0.05)。PSA≥4ng/ml时前列腺癌检出率随着PSA值的增高而上升。134例患者PSAD值为(1.09±1.72)ng/(ml·cm3),以PSAD≥0.19ng/(ml·cm3)为截点诊断前列腺癌的敏感度为95.59%(65/68),特异度为51.52%(34/66),阳性预测值67.01%(65/97),阴性预测值为32.99%(32/97)。4ng/mlPSA≤15ng/ml组中,以PSAD≥0.19ng/(ml.cm3)为截点诊断前列腺癌的敏感度为80.00%(8/10),特异度为71.05%(27/38),阳性预测值为42.11%(8/19),阴性预测值为57.89%(11/19)。前列腺癌组PSA及PSAD值均高于非前列腺癌组(P均0.05),PV小于非前列腺癌组(P0.05)。4ng/mlPSA≤15ng/ml组中,前列腺癌与非前列腺癌患者PSA及PV差异均无统计学意义(P均0.05),前列腺癌患者PSAD高于非前列腺癌患者(P0.05)。结论血清PSA及PSAD均与前列腺穿刺活检前列腺癌检出率有关,PSA15ng/ml应行穿刺活检,PSAD对4ng/mlPSA≤15ng/ml的患者是否应行穿刺活检具有指导意义。
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| 关 键 词： | 前列腺肿瘤|前列腺特异抗原|穿刺术|超声检查 |
| 收稿时间： | 3/3/2015 12:00:00 AM |
| 修稿时间： | 2015/8/31 0:00:00 |
Correlation of transrectal ultrasound guided prostate biopsy and serum oncentration of prostate specific antigen, prostate specific antigen density in diagnosis of prostatic carcinoma |
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| JIN Qiu-long,GUO Jian-feng,ZHENG Kai,GU Hua-yun,YAN Yu and ZHOU Yi-qun.Correlation of transrectal ultrasound guided prostate biopsy and serum oncentration of prostate specific antigen, prostate specific antigen density in diagnosis of prostatic carcinoma[J].Chinese Journal of Interventional Imaging and Therapy,2015,12(10):616-620. |
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| Authors: | JIN Qiu-long GUO Jian-feng ZHENG Kai GU Hua-yun YAN Yu and ZHOU Yi-qun |
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| Institution: | Department of Ultrasound, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China,Department of Ultrasound, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China,Department of Ultrasound, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China,Department of Ultrasound, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China,Department of Ultrasound, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China and Department of Ultrasound, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China |
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| Abstract: | |
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| Keywords: | Prostatic neoplasms Prostate-specific antigen Punctures Ultrasonography |
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